Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size.

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Research Abstract Details 

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Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Abstract Text:

James O Marx,M Charlotte Olsson,Lars Larsson,

To fully understand the effect of scaling on skeletal muscle shortening velocity (V (0)), it is important to know which phenotypic characteristics drive the changes between species. The purpose of the current investigation was to compare the effects of body mass and femur length, as an estimate of total limb length, on V (0) in species that cover a 100,000-fold range of body masses. Using the slack test procedure, V (0) was determined for fibers expressing types I and IIa myosin heavy chain (MyHC) isoforms in the mouse, rat, dog, human, horse, and rhinoceros under identical experimental conditions. A significant scaling effect on V (0) was detected when compared to body mass (type I fibers, r=0.95, p<0.01; type IIa fibers, r=0.83, p<0.05). However, the horse's V (0) for both fiber types was faster than the human's, despite having a 5-fold greater body mass than the human. When V (0) was scaled vs limb length, the strength of the relationships improved in fibers expressing both types I and IIa MyHC (r=0.98, p<0.001, and r=0.89, p<0.05, respectively) and scaled with the expected relationship, with the species with the shorter femur, the horse, having the faster V (0). A similar effect can be seen with stride frequency scaling more closely with limb length than body mass. These results suggest that limb length, not body mass, is a more relevant factor driving the scaling effect on skeletal muscle shortening velocity.

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Publishing Authors By Initials

JO Marx,MC Olsson,L Larsson,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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MEDLINE DATE:

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pflügers Archiv : European journal of physiology

VOLUME: 452

Page Numbers: 222-30

Journal Abbreviation: Pflugers Arch.

ISSN: 0031-6768

DAY: 7

MONTH: 12

YEAR: 2005

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Information

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LANGUAGE: eng

NlmUniqueID: 154720

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

Chemical & Substance for Abstract: Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size. Information

Substance Name: Myosin Heavy Chains

Registry Number: 0

Grant and Affiliation Information for Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size.

AFFILIATION: Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA.

Country: Germany

AGENCY: United States NIAMS

GRANT: AR47318

ACRONYM: AR

MEDLINETA: Pflugers Arch

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