Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity.

Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity. Research Abstract Details 

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Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity. Abstract Text:

Sang-Jip Nam,Hyunsil Ko,Moon Kyeong Ju,Hoosang Hwang,Jungwook Chin,Jungyeob Ham,Byoungchan Lee,Jaehwan Lee,Dong Hwan Won,Hyukjae Choi,Jaeyoung Ko,Kyoungjin Shin,Taekyung Oh,Seokho Kim,Jung-Rae Rho,Heonjoong Kang,Sang-Jip Nam,Hyunsil Ko,Moon Kyeong Ju,Hoosang Hwang,Jungwook Chin,Jungyeob Ham,Byoungchan Lee,Jaehwan Lee,Dong Hwan Won,Hyukjae Choi,Jaeyoung Ko,Kyoungjin Shin,Taekyung Oh,Seokho Kim,Jung-Rae Rho,Heonjoong Kang,Sang-Jip Nam,Hyunsil Ko,Moon Kyeong Ju,Hoosang Hwang,Jungwook Chin,Jungyeob Ham,Byoungchan Lee,Jaehwan Lee,Dong Hwan Won,Hyukjae Choi,Jaeyoung Ko,Kyoungjin Shin,Taekyung Oh,Seokho Kim,Jung-Rae Rho,Heonjoong Kang,

Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC 50 values of 2.4 and 24 microM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.

Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity. Publishing Authors By Initials

SJ Nam,H Ko,MK Ju,H Hwang,J Chin,J Ham,B Lee,J Lee,DH Won,H Choi,J Ko,K Shin,T Oh,S Kim,JR Rho,H Kang,SJ Nam,H Ko,MK Ju,H Hwang,J Chin,J Ham,B Lee,J Lee,DH Won,H Choi,J Ko,K Shin,T Oh,S Kim,JR Rho,H Kang,SJ Nam,H Ko,MK Ju,H Hwang,J Chin,J Ham,B Lee,J Lee,DH Won,H Choi,J Ko,K Shin,T Oh,S Kim,JR Rho,H Kang,

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Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1691-5

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 8

MONTH: 11

YEAR: 2007

Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

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Grant and Affiliation Information for Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity.

AFFILIATION: hjkang@snu.ac.kr.

Country: United States

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MEDLINETA: J Nat Prod

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