Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture.

Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Research Abstract Details 

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Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Abstract Text:

Randolph S Ashton,Akhilesh Banerjee,Supriya Punyani,David V Schaffer,Ravi S Kane,Randolph S Ashton,Akhilesh Banerjee,Supriya Punyani,David V Schaffer,Ravi S Kane,

We describe a method for creating alginate hydrogels with adjustable degradation rates that can be used as scaffolds for stem cells. Alginate hydrogels have been widely tested as three-dimensional constructs for cell culture, cell carriers for implantation, and in tissue regeneration applications; however, alginate hydrogel implants can take months to disappear from implantation sites because mammals do not produce endogenous alginases. By incorporating poly(lactide-co-glycolide) (PLGA) microspheres loaded with alginate lyase into alginate hydrogels, we demonstrate that alginate hydrogels can be enzymatically degraded in a controlled and tunable fashion. We demonstrate that neural progenitor cells (NPCs) can be cultured and expanded in vitro in this degradable alginate hydrogel system. Moreover, we observe a significant increase in the expansion rate of NPCs cultured in degrading alginate hydrogels versus NPCs cultured in standard, i.e. non-degrading, alginate hydrogels. Degradable alginate hydrogels encapsulating stem cells may be widely applied to develop novel therapies for tissue regeneration.

Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Publishing Authors By Initials

RS Ashton,A Banerjee,S Punyani,DV Schaffer,RS Kane,RS Ashton,A Banerjee,S Punyani,DV Schaffer,RS Kane,

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Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomaterials

VOLUME: 28

Page Numbers: 5518-25

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 19

MONTH: 09

YEAR: 2007

Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture.

AFFILIATION: The Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

Country: England

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MEDLINETA: Biomaterials

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