Scaffold proteins in mammalian MAP kinase cascades.

Scaffold proteins in mammalian MAP kinase cascades. Research Abstract Details 

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Scaffold proteins in mammalian MAP kinase cascades. Abstract Text:

Katsuji Yoshioka,

The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to humans, is activated in response to a variety of extra- and intracellular stimuli, and plays key roles in multiple cellular processes, including proliferation, differentiation, and apoptosis. The MAPK pathway transmits its signal through the sequential phosphorylation of MAPK kinase kinase to MAPK kinase to MAPK. Specific and efficient activation of the MAPK cascades is crucial for proper cellular responses to stimuli. As shown in yeast, the mammalian MAPK signaling system may also employ scaffold proteins, in part, to organize the MAPK signaling components into functional MAPK modules, thereby enabling the efficient activation of specific MAPK pathways. This review article describes recent advances in the study of potential mammalian scaffold proteins that may help us understand the complex regulation, including the spatial and temporal control, of the mammalian MAPK signaling pathways.

Scaffold proteins in mammalian MAP kinase cascades. Publishing Authors By Initials

K Yoshioka,

For similar proteins: nuclear proteins: nuclear matrix-associated proteins research abstracts see: proteins: nuclear proteins: nuclear matrix-associated proteins research

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Scaffold proteins in mammalian MAP kinase cascades. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 135

Page Numbers: 657-61

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 2004

Scaffold proteins in mammalian MAP kinase cascades. Information

Number of References: 55

LANGUAGE: eng

NlmUniqueID: 376600

Scaffold proteins in mammalian MAP kinase cascades. Keywords Mesh Terms:

KEYWORDS: Nuclear Matrix-Associated Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Scaffold proteins in mammalian MAP kinase cascades. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Scaffold proteins in mammalian MAP kinase cascades.

AFFILIATION: Division of Cell Cycle Regulation, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Takara-machi 13-1, Kanazawa 920-0934, Japan. katsuji@kenroku.kanazawa-u.ac.jp

Country: Japan

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MEDLINETA: J Biochem

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