Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.

Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Research Abstract Details 

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Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Abstract Text:

Atsunori Tsuchiya,Toshio Heike,Shiro Baba,Hisanori Fujino,Katsutsugu Umeda,Yasunobu Matsuda,Minoru Nomoto,Takafumi Ichida,Yutaka Aoyagi,Tatsutoshi Nakahata,Atsunori Tsuchiya,Toshio Heike,Shiro Baba,Hisanori Fujino,Katsutsugu Umeda,Yasunobu Matsuda,Minoru Nomoto,Takafumi Ichida,Yutaka Aoyagi,Tatsutoshi Nakahata,

The liver has a high potential to regenerate however, the relation between oval cells and endothelial cells in the portal area during liver regeneration has not been adequately described. We have focused on sca-1+ endothelial cells (SPEC: sca-1+CD31+CD45- cells) and analyzed their localization, growth potential, and the role of these cells in damaged liver. SPECs are localized in the portal area and comprise approximately 20-30% of CD31+CD45- cells. These cells have higher growth potential than sca-1- endothelial cells and grow aggressively when the liver is severely damaged on the lateral side of the oval cells. In an in vivo study we show that when the liver is severely damaged in the presence of a VEGF (vascular endothelial growth factor)-inhibitor, the frequency of SPECs decreased and the recovery of liver volume was also delayed. These results strongly suggest that SPECs play important roles in the recovery of severely damaged liver.

Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Publishing Authors By Initials

A Tsuchiya,T Heike,S Baba,H Fujino,K Umeda,Y Matsuda,M Nomoto,T Ichida,Y Aoyagi,T Nakahata,A Tsuchiya,T Heike,S Baba,H Fujino,K Umeda,Y Matsuda,M Nomoto,T Ichida,Y Aoyagi,T Nakahata,

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Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 365

Page Numbers: 595-601

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 5

MONTH: 11

YEAR: 2007

Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.

AFFILIATION: Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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