SC 23992: radioreceptor assays for therapeutic and side effects.

SC 23992: radioreceptor assays for therapeutic and side effects. Research Abstract Details 

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SC 23992: radioreceptor assays for therapeutic and side effects. Abstract Text:

J W Funder,J Mercer,J Hood,

1. A new spirolactone (SC 23992) has been assayed in vitro to determine its affinity for mineralocorticoid and androgen receptors. 2. Although two to eight times as potent as anti-aldosterone agent as Aldactone in vivo, SC 23992 has only approximately 10% the potency in vitro. 3. This discrepancy between potency in vivo and in vitro appears to be explained on radioreceptor assay of the principal metabolites of Aldactone SC 23992. 4. SC 23992 may represent an antimineralocorticoid with less antiandrogen side effects.

SC 23992: radioreceptor assays for therapeutic and side effects. Publishing Authors By Initials

JW Funder,J Mercer,J Hood,

For similar organic chemicals: lactones: spironolactone research abstracts see: organic chemicals: lactones: spironolactone research

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SC 23992: radioreceptor assays for therapeutic and side effects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 3

Page Numbers: 333s-334s

Journal Abbreviation:

ISSN: 0144-4107

DAY: 12

MONTH: Dec

YEAR: 1976

SC 23992: radioreceptor assays for therapeutic and side effects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7907311

SC 23992: radioreceptor assays for therapeutic and side effects. Keywords Mesh Terms:

KEYWORDS: Spironolactone

MESH TERMS: pharmacology

Chemical & Substance for Abstract: SC 23992: radioreceptor assays for therapeutic and side effects. Information

Substance Name: Spironolactone

Registry Number: 52-01-7

Grant and Affiliation Information for SC 23992: radioreceptor assays for therapeutic and side effects.

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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