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Satellite cell proliferation and skeletal muscle hypertrophy.

Satellite cell proliferation and skeletal muscle hypertrophy. Research Abstract Details 

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  • Satellite cell proliferation and skeletal muscle hypertrophy. Abstract Text:

    gregory r adamsGregory R Adams,

    Satellite cells are small, mononuclear cells found in close association with striated skeletal muscles cells (myofibers). These cells appear to function as reserve myoblasts. A critical role for these cells in the process of muscle regeneration following injury has been clearly established. In that role, satellite cells have been shown to proliferate extensively. Some of the progeny of these cells then fuse with each other to form replacement myofibers, whereas others return to quiescence, thereby maintaining this reserve population. In response to injury, activated satellite cells can also fuse with damaged but viable myofibers to promote repair and regeneration. It has also been observed that satellite cells are activated during periods of significantly increased muscle loading and that some of these cells fuse with apparently undamaged myofibers as part of the hypertrophy process. The observation that the inactivation of satellite cell proliferation prevents most of the hypertrophy response to chronic increases in loading has lead to the hypothesis that a limitation to the expansion of myofiber size is imposed by the number of myonuclei present. Recent evidence suggests that a potential limitation to muscle hypertrophy, in the absence of a reserve supply of myonuclei, may be the inability to sustain increases in ribosomes, thereby limiting translational capacity.

    Satellite cell proliferation and skeletal muscle hypertrophy. Publishing Authors By Initials

    gr adamsGR Adams,

    For similar cells: myoblasts: myoblasts, skeletal: satellite cells, skeletal muscle research abstracts see: cells: myoblasts: myoblasts, skeletal: satellite cells, skeletal muscle research

    PUBMED ID PMID:

    MEDLINE DATE:

    Satellite cell proliferation and skeletal muscle hypertrophy. Journal Published:

    PUBLICATION TYPE: Review

    Journal: Applied physiology, nutrition, and metabolism = Ph

    VOLUME: 31

    Page Numbers: 782-90

    Journal Abbreviation:

    ISSN: 1715-5312

    DAY: 3

    MONTH: Dec

    YEAR: 2006

    Satellite cell proliferation and skeletal muscle hypertrophy. Information

    Number of References: 83

    LANGUAGE: eng

    NlmUniqueID: 101264333

    Satellite cell proliferation and skeletal muscle hypertrophy. Keywords Mesh Terms:

    KEYWORDS: Satellite Cells, Skeletal Muscle

    MESH TERMS: physiology

    Chemical & Substance for Abstract: Satellite cell proliferation and skeletal muscle hypertrophy. Information

    Substance Name:

    Registry Number:

    Grant and Affiliation Information for Satellite cell proliferation and skeletal muscle hypertrophy.

    AFFILIATION: Department of Physiology and Biophysics, Medical Science I D335, University of California, Irvine, CA 92697, USA. gradams@uci.edu

    Country: Canada

    Canada Research PublicationCanada Research Publication

    AGENCY: United States NICHD

    GRANT: R01 HD-39676

    ACRONYM: HD

    MEDLINETA: Appl Physiol Nutr Metab

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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