Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures.

Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Research Abstract Details 

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Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Abstract Text:

S Otake,

OBJECTIVE. Muscular involvement of sarcoidosis is rare and occurs in two forms: nodular and myopathic. In the nodular variety, patients have single or multiple nodules in the skeletal muscles. Patients with the myopathic type have myalgia, muscle weakness, and atrophy. The purpose of this study was to determine the imaging features of these two types of muscular sarcoidosis and to compare the merits of different imaging procedures in establishing the diagnosis. MATERIALS AND METHODS. I retrospectivity reviewed the imaging findings of 28 patients with proved muscular sarcoidosis: 20 patients with the nodular type and eight with the myopathic type. Of the 20 patients with the nodular type, 20 had MR imaging, 17 had 67Ga scintigraphy, 10 had CT, six had sonography, and two had angiography. All eight patients with the myopathic type had MR imaging, and six of them had 67Ga scintigraphy. RESULTS. In the nodular type of muscular sarcoidosis, the lesions were long and extended along muscle fibers. Axial MR images showed a star-shaped central structure of decreased signal intensity. Coronal and sagittal MR images showed three stripes, including an inner stripe of decreased signal intensity and outer stripes of increased signal intensity. After IV injection of gadopentetate dimeglumine, contrast-enhanced MR images showed enhancement in the peripheral area of the lesions of the nodular type. On sonograms, the central structure was hyperechoic and the peripheral area was hypoechoic relative to surrounding tissue. 67Ga scintigraphy showed increased uptake of radionuclide in the nodules. CT and angiography were of less diagnostic value. In the myopathic type, MR images showed no abnormalities. Myopathic involvement was visualized only with 67Ga scintigraphy, which showed diffusely increased uptake of radionuclide. CONCLUSION. The unusual MR findings seen in the patients studied were suggestive of the nodular type of muscular sarcoidosis. 67Ga scintigraphy was useful for evaluating the whole body in patients with the nodular type and was the only imaging method that could show the myopathic type of involvement.

Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Publishing Authors By Initials

S Otake,

For similar hemic and lymphatic diseases: lymphatic diseases: lymphoproliferative disorders: sarcoidosis research abstracts see: hemic and lymphatic diseases: lymphatic diseases: lymphoproliferative disorders: sarcoidosis research

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Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 162

Page Numbers: 369-75

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ISSN: 0361-803X

DAY: 15

MONTH: Feb

YEAR: 1994

Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures. Keywords Mesh Terms:

KEYWORDS: Sarcoidosis

MESH TERMS: diagnosis

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Grant and Affiliation Information for Sarcoidosis involving skeletal muscle: imaging findings and relative value of imaging procedures.

AFFILIATION: Department of Radiology, Nagoya City University Medical School, Aichi, Japan.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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