Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro.

Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Research Abstract Details 

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Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Abstract Text:

Daniel H Fine,David Furgang,Daniel Goldman,

BACKGROUND: Previous research indicated that patients with localized aggressive periodontitis (LAgP) had minimal proximal decay. We speculated that differences in these two proximal dental diseases (LAgP and proximal decay) in LAgP could be due to the effect of saliva on the growth of key microorganisms related to these two infections. Carbon dioxide (CO(2)) is required for growth of Actinobacillus actinomycetemcomitans (Aa), the reputed cause of LAgP. Bicarbonate, a source of CO(2), buffers acid production by Streptococcus mutans (Sm), a key organism associated with caries. The purpose of this study was to determine whether the saliva of LAgP patients and subjects with Aa had higher levels of bicarbonate, or an elevated pH, and/or reduced survival of Sm. METHODS: Eleven Aa-positive subjects (seven with LAgP) were matched with 11 Aa-negative controls. A total of 5 ml saliva obtained from each subject was tested for CO(2) levels, pH, and effects on survival of Aa and Sm. Saliva from 22 additional subjects was used for confirmatory data. RESULTS: CO(2) levels in the test group (Aa-positive subjects) and controls (Aa-negatives) were similar. No clinically relevant differences were found in salivary pH. However, saliva from the test group killed Sm by more than two logs (P <0.05). No effect was seen on Aa. The saliva from the Aa-negative group killed Aa by two logs (P <0.05). No effect was seen on Sm. CONCLUSION: Aa-positive subjects had a salivary factor that significantly reduced survival of Sm, which may help to explain the fact that this group typically has minimal proximal decay.

Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Publishing Authors By Initials

DH Fine,D Furgang,D Goldman,

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: viridans streptococci: streptococcus mutans research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: viridans streptococci: streptococcus mutans research

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Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of periodontology

VOLUME: 78

Page Numbers: 518-26

Journal Abbreviation: J. Periodontol.

ISSN: 0022-3492

DAY: 3

MONTH: Mar

YEAR: 2007

Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 8000345

Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Keywords Mesh Terms:

KEYWORDS: Streptococcus mutans

MESH TERMS: metabolism

Chemical & Substance for Abstract: Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro. Information

Substance Name: Carbon Dioxide

Registry Number: 124-38-9

Grant and Affiliation Information for Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitro.

AFFILIATION: Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, NJ 07101, USA. finedh@umdnj.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE-016474

ACRONYM: DE

MEDLINETA: J Periodontol

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