Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity.

Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Research Abstract Details 

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Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Abstract Text:

Jenney S Kim,Pratip Nag,Alan L Landay,Mario Alves,Mardge H Cohn,James W Bremer,Linda L Baum,

HIV is not usually transmitted by saliva from HIV-1-infected individuals. Antiviral substances in saliva responsible for this may include HIV-1-specific antibody-dependent cell-mediated cytotoxicity (ADCC). We evaluated saliva ADCC titers of 62 HIV-1-infected women from the Women's Interagency HIV Study (WIHS) and 55 uninfected individuals. HIV-1-infected women were less likely to have ADCC activity in saliva than in serum or cervical lavage fluid (CVL). 24% of HIV-1-positive women and a similar percentage of uninfected women had HIV-1-specific saliva ADCC activity. A significant amount of saliva ADCC activity in infected women was HIV-gp120-specific. These studies demonstrate that HIV-specific ADCC activity can be present in saliva. This activity may contribute to host defence against initial infection with HIV.

Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Publishing Authors By Initials

JS Kim,P Nag,AL Landay,M Alves,MH Cohn,JW Bremer,LL Baum,

For similar investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research abstracts see: investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research

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MEDLINE DATE:

Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: FEMS immunology and medical microbiology

VOLUME: 48

Page Numbers: 267-73

Journal Abbreviation: FEMS Immunol. Med. Microbiol.

ISSN: 0928-8244

DAY: 18

MONTH: 09

YEAR: 2006

Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9315554

Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Keywords Mesh Terms:

KEYWORDS: Viral Load

MESH TERMS: virology

Chemical & Substance for Abstract: Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity. Information

Substance Name: Immunoglobulin A

Registry Number: 0

Grant and Affiliation Information for Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity.

AFFILIATION: Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: U01-AI-34993

ACRONYM: AI

MEDLINETA: FEMS Immunol Med Microbiol

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