Saliva-based diagnostics using 16S rRNA microarrays and microfluidics.

Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Research Abstract Details 

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Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Abstract Text:

E Michelle Starke,James C Smoot,Jer-Horng Wu,Wen-Tso Liu,Darrell Chandler,David A Stahl,

The development of a diagnostic system based on DNA microarrays for rapid identification and enumeration of microbial species in the oral cavity is described. This system uses gel-based microarrays with immobilized probes designed within a phylogenetic framework that provides for comprehensive microbial monitoring. Understanding the community structure in the oral cavity is a necessary foundation on which to understand the breadth and depth of different microbial communities in the oral cavity and their role in acute and systemic disease. Our ultimate goal is to develop a diagnostic device to identify individuals at high risk for oral disease, and thereby reduce its prevalence and therefore the economic burden associated with treatment. This article discusses recent improvements of our system in reducing diffusional constraints in order to provide more rapid and accurate measurements of the microbial composition of saliva.

Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Publishing Authors By Initials

EM Starke,JC Smoot,JH Wu,WT Liu,D Chandler,DA Stahl,

For similar fluids and secretions: bodily secretions: saliva research abstracts see: fluids and secretions: bodily secretions: saliva research

PUBMED ID PMID:

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Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1098

Page Numbers: 345-61

Journal Abbreviation:

ISSN: 0077-8923

DAY: 3

MONTH: Mar

YEAR: 2007

Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7506858

Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Keywords Mesh Terms:

KEYWORDS: Saliva

MESH TERMS: chemistry

Chemical & Substance for Abstract: Saliva-based diagnostics using 16S rRNA microarrays and microfluidics. Information

Substance Name: RNA, Ribosomal, 16S

Registry Number: 0

Grant and Affiliation Information for Saliva-based diagnostics using 16S rRNA microarrays and microfluidics.

AFFILIATION: Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195-2700, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: U01 DE14955

ACRONYM: DE

MEDLINETA: Ann N Y Acad Sci

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