Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola.

Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Research Abstract Details 

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Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Abstract Text:

Philip G Williams,Ratnakar N Asolkar,Tamara Kondratyuk,John M Pezzuto,Paul R Jensen,William Fenical,

An extensive study of the secondary metabolites produced by several strains of the marine actinomycete Salinispora arenicola has led to the isolation of two unusual bicyclic polyketides, saliniketals A and B (1, 2). The structures, which contain a new 1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl ring, were assigned mainly by 2D NMR spectroscopic methods. Unexpectedly, chemical derivatization of saliniketal A with Mosher's acid chloride resulted in a functional group interconversion of an unsaturated primary amide to the corresponding nitrile in a quantitative yield under unusually mild conditions. Saliniketals A and B were found to inhibit ornithine decarboxylase induction, an important target for the chemoprevention of cancer, with IC50 values of 1.95 +/- 0.37 and 7.83 +/- 1.2 microg/mL, respectively.

Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Publishing Authors By Initials

PG Williams,RN Asolkar,T Kondratyuk,JM Pezzuto,PR Jensen,W Fenical,

For similar enzymes and coenzymes: enzymes: lyases: carbon-carbon lyases: carboxy-lyases: ornithine decarboxylase research abstracts see: enzymes and coenzymes: enzymes: lyases: carbon-carbon lyases: carboxy-lyases: ornithine decarboxylase research

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Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 83-8

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 3

MONTH: Jan

YEAR: 2007

Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Keywords Mesh Terms:

KEYWORDS: Ornithine Decarboxylase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. Information

Substance Name: Ornithine Decarboxylase

Registry Number: EC 4.1.1.17

Grant and Affiliation Information for Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola.

AFFILIATION: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California - San Diego, La Jolla, California 92093-0204, USA.

Country: United States

AGENCY: United States NCRR

GRANT: S10RR017768

ACRONYM: RR

MEDLINETA: J Nat Prod

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