Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective.

Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Research Abstract Details 

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Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Abstract Text:

Michal T Krauze,Scott R Vandenberg,Yoji Yamashita,Ryuta Saito,John Forsayeth,Charles Noble,John Park,Krystof S Bankiewicz,

Convection-enhanced delivery (CED) is gaining popularity in direct brain infusions. Our group has pioneered the use of liposomes loaded with the MRI contrast reagent as a means to track and quantitate CED in the primate brain through real-time MRI. When co-infused with therapeutic nanoparticles, these tracking liposomes provide us with unprecedented precision in the management of infusions into discrete brain regions. In order to translate real-time CED into clinical application, several important parameters must be defined. In this study, we have analyzed all our cumulative animal data to answer a number of questions as to whether real-time CED in primates depends on concentration of infusate, is reproducible, allows prediction of distribution in a given anatomic structure, and whether it has long term pathological consequences. Our retrospective analysis indicates that real-time CED is highly predictable; repeated procedures yielded identical results, and no long-term brain pathologies were found. We conclude that introduction of our technique to clinical application would enhance accuracy and patient safety when compared to current non-monitored delivery trials.

Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Publishing Authors By Initials

MT Krauze,SR Vandenberg,Y Yamashita,R Saito,J Forsayeth,C Noble,J Park,KS Bankiewicz,

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Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental neurology

VOLUME: 210

Page Numbers: 638-44

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 27

MONTH: 12

YEAR: 2007

Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Information

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LANGUAGE: eng

NlmUniqueID: 370712

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AFFILIATION: Laboratory for Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.

Country: United States

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MEDLINETA: Exp Neurol

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