Safety data on zimelidine hydrochloride following an overdose.

Safety data on zimelidine hydrochloride following an overdose. Research Abstract Details 

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Safety data on zimelidine hydrochloride following an overdose. Abstract Text:

A Georgotas,J Mann,D Bush,S Gershon,

Zimelidine, a new antidepressant, has proved to be a potent and selective inhibitor of 5-HT uptake into central 5-HT neurons. Due to its structural differences from the tricyclic antidepressants, it has also been suggested that it may have a different pharmacological profile, and be devoid of anticholinergic and noradrenaline potentiating properties. During the treatment with zimelidine hydrochloride, as a part of an open trial, one of our patients, a 38-year-old chronically depressed woman, overdosed herself with more than 10 times the actual therapeutic dose of zimelidine with no undesirable side effects. Previous studies have indicated that zimelidine in comparison with imipramine and chlorimipramine has no, or at most, a slight effect on peripheral adrenergic neurons, and has less pronounced anticholinergic properties than imipramine. The findings of our overdose case provide some support for these findings.

Safety data on zimelidine hydrochloride following an overdose. Publishing Authors By Initials

A Georgotas,J Mann,D Bush,S Gershon,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyridines: pheniramine: brompheniramine: zimeldine research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyridines: pheniramine: brompheniramine: zimeldine research

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Safety data on zimelidine hydrochloride following an overdose. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 290

Page Numbers: 257-61

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 1981

Safety data on zimelidine hydrochloride following an overdose. Information

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LANGUAGE: eng

NlmUniqueID: 370365

Safety data on zimelidine hydrochloride following an overdose. Keywords Mesh Terms:

KEYWORDS: Zimeldine

MESH TERMS: poisoning

Chemical & Substance for Abstract: Safety data on zimelidine hydrochloride following an overdose. Information

Substance Name: Brompheniramine

Registry Number: 86-22-6

Grant and Affiliation Information for Safety data on zimelidine hydrochloride following an overdose.

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Country: DENMARK

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MEDLINETA: Acta Psychiatr Scand Suppl

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