Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh.

Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Research Abstract Details 

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Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Abstract Text:

Gary L Darmstadt,M Monir Hossain,Yoonjoung Choi,Mahfuza Shirin,Luke C Mullany,Maksuda Islam,Samir K Saha,

BACKGROUND: Chlorhexidine cleansing of newborn skin is a highly promising intervention for reducing neonatal mortality in developing countries, yet little is known of the mechanism of action. This study examined the impact of a single skin cleansing of hospitalized newborn infants in Bangladesh with baby wipes containing 0.25% chlorhexidine on both qualitative and quantitative skin flora. METHODS: Within 72 hours of birth, the skin of newborns admitted to Dhaka Shishu Hospital was wiped with baby wipes containing 0.25% chlorhexidine (n = 67) or placebo (n = 66) solution. Skin condition was assessed and skin swabs were taken from 3 sites (axillary, peri-umbilical, inguinal) at baseline and 2 hours, 24 hours, 3 days and 7 days after treatment. Skin flora was quantified and colonizing species were identified. FINDINGS: Skin cleansing with chlorhexidine had no adverse effects on skin condition, and resulted in minimal reduction (mean 0.5 degrees C) in body temperature. Positive skin culture rates 2 hours after skin cleansing were approximately 35%-55% lower than the baseline rates for placebo and chlorhexidine groups at all 3 sites. For the chlorhexidine group, positive skin culture rates remained significantly lower than the baseline rates for 24 hours to 3 days, whereas for the placebo group, beyond the first 2-hour follow-up, these values were not lower than baseline in any of the 3 sites. INTERPRETATION: Chlorhexidine skin treatment produced more extended skin cleansing effects than the placebo treatment. It is possible that the quantitative and qualitative reductions observed in the skin flora might contribute to reducing neonatal infections.

Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Publishing Authors By Initials

GL Darmstadt,MM Hossain,Y Choi,M Shirin,LC Mullany,M Islam,SK Saha,

For similar therapeutics: hygiene: skin care research abstracts see: therapeutics: hygiene: skin care research

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MEDLINE DATE:

Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Pediatric infectious disease journal

VOLUME: 26

Page Numbers: 492-5

Journal Abbreviation: Pediatr. Infect. Dis. J.

ISSN: 0891-3668

DAY: 3

MONTH: Jun

YEAR: 2007

Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701858

Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Keywords Mesh Terms:

KEYWORDS: Skin Care

MESH TERMS: methods

Chemical & Substance for Abstract: Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. Information

Substance Name: Chlorhexidine

Registry Number: 55-56-1

Grant and Affiliation Information for Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh.

AFFILIATION: Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. gdarmsta@jhsph.edu

Country: United States

AGENCY: United States NICHD

GRANT: HD44004

ACRONYM: HD

MEDLINETA: Pediatr Infect Dis J

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