S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase.

S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase. Research Abstract Details 

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S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase. Abstract Text:

Victor Aguilar,Samira Alliouachene,Athanassia Sotiropoulos,Andrew Sobering,Yoni Athea,Fatima Djouadi,Sylvain Miraux,Eric ,Marc Foretz,Benoit Viollet,Philippe Diolez,Jean Bastin,Paule Benit,Pierre Rustin,David Carling,Marco Sandri, Ventura-Clapier,Mario Pende,

S6 kinase (S6K) deletion in metazoans causes small cell size, insulin hypersensitivity, and metabolic adaptations; however, the underlying molecular mechanisms are unclear. Here we show that S6K-deficient skeletal muscle cells have increased AMP and inorganic phosphate levels relative to ATP and phosphocreatine, causing AMP-activated protein kinase (AMPK) upregulation. Energy stress and muscle cell atrophy are specifically triggered by the S6K1 deletion, independent of S6K2 activity. Two known AMPK-dependent functions, mitochondrial biogenesis and fatty acid beta-oxidation, are upregulated in S6K-deficient muscle cells, leading to a sharp depletion of lipid content, while glycogen stores are spared. Strikingly, AMPK inhibition in S6K-deficient cells restores cell growth and sensitivity to nutrient signals. These data indicate that S6K1 controls the energy state of the cell and the AMPK-dependent metabolic program, providing a mechanism for cell mass accumulation under high-calorie diet.

S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase. Publishing Authors By Initials

V Aguilar,S Alliouachene,A Sotiropoulos,A Sobering,Y Athea,F Djouadi,S Miraux,E ,M Foretz,B Viollet,P Diolez,J Bastin,P Benit,P Rustin,D Carling,M Sandri,R Ventura-Clapier,M Pende,

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S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell metabolism

VOLUME: 5

Page Numbers: 476-87

Journal Abbreviation: Cell Metab.

ISSN: 1550-4131

DAY: 6

MONTH: Jun

YEAR: 2007

S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase. Information

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LANGUAGE: eng

NlmUniqueID: 101233170

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AFFILIATION: INSERM, U845, Paris F-75015, France; Université Paris Descartes, UMRS-845, Paris F-75015, France.

Country: United States

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MEDLINETA: Cell Metab

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