S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy.

S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy. Research Abstract Details 

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S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy. Abstract Text:

A R Khan,

Background: A definitive diagnosis of tuberculoid and borderline tuberculoid leprosy is based on a demonstration of either acid-fast bacilli or nerve elements within the granulomas. On routine hematoxylin and eosin stains, the nerve fibers are not easily identifiable. In this study, we used S-100 protein to highlight the nerve elements and to count their numbers in leprosy and non-leprosy granulomas. Materials and Methods: Skin biopsy specimens from 15 cases of tuberculoid/borderline tuberculoid leprosy and 14 cases belonging to other granulomatous diseases of the skin were stained with S-100 protein. The surface area of all the biopsies was calculated and the number of nerve bundles stained with S-100 protein were counted in each specimen. Results: The nerve bundles were 15 per cm 2 in leprosy cases, and 9.2 per cm2 in non-leprosy cases. In addition, the leprosy cases showed longer nerve twigs that were perpendicularly oriented to the skin surface. Conclusion: Immunostaining with S-100 facilitated detection of nerve elements in tuberculoid/borderline tuberculoid leprosy. Also, an increased number of nerve elements were found in leprosy granulomas when compared with non-leprosy granulomas (P=<0.05).

S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy. Publishing Authors By Initials

AR Khan,

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S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of Saudi medicine

VOLUME: 18

Page Numbers: 305-7

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ISSN: 0256-4947

DAY: 8

MONTH: 03

YEAR: 2007

S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy. Information

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LANGUAGE: eng

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Grant and Affiliation Information for S-100 protein in the diagnosis of tuberculoid/borderline tuberculoid leprosy.

AFFILIATION: Department of Pathology, College of Medicine, King Saud University, Abha, Saudi Arabia.

Country: Saudi Arabia

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MEDLINETA: Ann Saudi Med

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