Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Research Abstract Details 

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Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Abstract Text:

Min Chen,Nicole Kilgore,Kuo-Hsiung Lee,Dao-Feng Chen,

Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans rubrisandrins A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques. Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Publishing Authors By Initials

M Chen,N Kilgore,KH Lee,DF Chen,

For similar plants: plant families and groups: angiosperms: schisandraceae: schisandra research abstracts see: plants: plant families and groups: angiosperms: schisandraceae: schisandra research

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Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 69

Page Numbers: 1697-701

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 3

MONTH: Dec

YEAR: 2006

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906882

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Keywords Mesh Terms:

KEYWORDS: Schisandra

MESH TERMS: chemistry

Chemical & Substance for Abstract: Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Information

Substance Name: rubrisandrin B

Registry Number: 0

Grant and Affiliation Information for Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.

AFFILIATION: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.

Country: United States

AGENCY: United States NIAID

GRANT: AI 33066

ACRONYM: AI

MEDLINETA: J Nat Prod

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