Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors.

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Abstract Text:

Hajime Hirata,Soushi Sonoda,Shun Agui,Mariko Yoshida,Kousaku Ohinata,Masaaki Yoshikawa,Hajime Hirata,Soushi Sonoda,Shun Agui,Mariko Yoshida,Kousaku Ohinata,Masaaki Yoshikawa,

Rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) is a delta opioid peptide derived from the large subunit of spinach d-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). We previously reported that rubiscolin-6 had an analgesic effect and stimulated memory consolidation. Here we show that intraperitoneally (i.p.) or orally administered rubiscolin-6 has an anxiolytic effect at a dose of 10 mg/kg or 100 mg/kg, respectively, in the elevated plus-maze test in mice. The anxiolytic effects of rubscolin-6 after i.p. (10 mg/kg) and oral (100 mg/kg) administration were blocked by a delta opioid receptor antagonist, naltrindole (1 mg/kg, s.c.), suggesting that the anxiolytic activity of rubiscolin-6 is mediated by delta opioid receptor. The anxiolytic effect of rubiscolin-6 (10 mg/kg, i.p.) was also blocked by a dopamine D(1) antagonist, SCH23390 (30 microg/kg, i.p.), but not by a dopamine D(2) antagonist, raclopride (15 microg/kg, i.p.). The anxiolytic effect of rubiscolin-6 (10 mg/kg, i.p.) was blocked by sigma(1) receptor antagonist, BMY14802 (0.5 mg/kg, i.p.) or BD1047 (10 mg/kg, i.p.). Taken together, the anxiolytic effect of rubiscolin-6 is mediated by sigma(1) and dopamine D(1) receptors downstream of delta opioid receptor.

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Publishing Authors By Initials

H Hirata,S Sonoda,S Agui,M Yoshida,K Ohinata,M Yoshikawa,H Hirata,S Sonoda,S Agui,M Yoshida,K Ohinata,M Yoshikawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Peptides

VOLUME: 28

Page Numbers: 1998-2003

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 27

MONTH: 07

YEAR: 2007

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008690

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors.

AFFILIATION: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Peptides

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors Related Publications

• Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis.
• Biological characters of bats in relation to natural reservoir of emerging viruses.
• Candida soluble cell wall beta-D-glucan induces lung inflammation in mice.
• Characterization of virus-induced gene silencing in tobacco plants infected with apple latent spherical virus.
• Cheravirus and Sadwavirus: two unassigned genera of plant positive-sense single-stranded RNA viruses formerly considered atypical members of the genus Nepovirus (family Comoviridae).
• Contribution Of Oxidative Stress To Protein Catabolism In Skeletal Muscle: 1856: Board #144 May 31 9:00 AM - 10:30 AM.
• Correction of deformity and shortening due to post traumatic epiphyseal arrest by distraction osteogenesis.
• Development of an intermolecular transposition assay system in Bacillus subtilis 168 using IS4Bsu1 from Bacillus subtilis (natto).
• First-line therapy for theophylline-associated seizures.
• Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease.
• Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
• Increased intestinal luminal carbon monoxide gas in patients with ulcerative colitis.
• Intra-extradural plexiform schwannoma of the cervical spine.
• Involvement of BMP-2 signaling in a cartilage cap in osteochondroma.
• Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte.
• Long-term follow-up of juvenile acute nonproliferative glomerulitis (JANG).
• New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
• Reduction of Visceral Adiposity Underlies the Improvement of Arterial Stiffness through Aerobic Exercise Training: 1529: Board #19 May 30 3:30 PM 5:00 PM.
• Resonance Raman spectra of the FMN of the bovine heart NADH: ubiquinone oxidoreductase, the largest membrane protein in the mitochondrial respiratory system.
• Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in mice.
• Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors.
• Surgical outcomes after treatment of fractures in femur and tibia in pycnodysostosis.
• The effects of antipoverty programs on children's cumulative level of poverty-related risk.
• The mode of destruction in shoulders with rheumatoid arthritis based on radiographic findings.
• Thermodynamic quantities of surface formation of aqueous electrolyte solutions VII. Aqueous solution of alkali metal nitrates LiNO3, NaNO3, and KNO3.
• Treatment of temporomandibular pain with the selective serotonin reuptake inhibitor paroxetine.
• Up-regulation of thrombin activity induced by vascular endothelial growth factor in asthmatic airways.
• Working nonstandard schedules and variable shifts in low-income families: associations with parental psychological well-being, family functioning, and child well-being.
• [Randomized controlled clinical trials for IgA nephropathies]
• beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.