RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness.

RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Research Abstract Details 

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RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Abstract Text:

Min Zhang,Saleh Altuwaijri,Shuyuan Yeh,

RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular matrix (ECM) is the first barrier that tumor cells encounter. Therefore, we tested the effect of VES on the invasion of different prostate tumor cells, PC-3, DU-145, and LNCaP, through Matrigel, a reconstituted ECM, using an in vitro cell invasion assay. The invasion of PC-3 and DU-145 cells through Matrigel was inhibited by 20 microM VES after treating for 24 h. The condition did not alter cell survival, cell cycle, cell adhesion or cell motility. We further investigated whether the ability of VES to inhibit prostate cancer cell invasiveness was associated with its ability to inhibit the activity of matrix metalloproteinases (MMPs), the key enzymes in the proteolysis of basement membrane during invasion. PC-3 and DU-145 cells that were treated with VES showed a significant reduction in the levels of MMP-9 in the culture medium. In contrast, LNCaP cells, which did not secrete MMP-9, were poorly invasive in Matrigel and were hardly affected by treatment with VES. This is the first report suggesting that VES inhibits human prostate cancer cell invasiveness and the reduction of secreted MMP-9 activity could be one of the contributory factors, which points to the potential use of VES in the prevention and therapy of prostate cancer invasion.

RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Publishing Authors By Initials

M Zhang,S Altuwaijri,S Yeh,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Oncogene

VOLUME: 23

Page Numbers: 3080-8

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 15

MONTH: Apr

YEAR: 2004

RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Information

Substance Name: Matrix Metalloproteinase 9

Registry Number: EC 3.4.24.35

Grant and Affiliation Information for RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness.

AFFILIATION: Departments of Urology and Pathology, University of Rochester, Rochester, NY 14642, USA.

Country: England

AGENCY: United States NIDDK

GRANT: DK60912

ACRONYM: DK

MEDLINETA: Oncogene

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