RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells.

RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Research Abstract Details 

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RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Abstract Text:

S Kidao,B G Sanders,K Kline,

RRR-alpha-tocopheryl succinate (vitamin E succinate) was studied for its effects on interleukin-2 (IL-2) production by chicken splenic derived T lymphocytes and murine EL-4 thymic lymphoma cells. Supernatants from 0.1 microgram/mL vitamin E succinate-supplemented chicken splenic T cell cultures exhibited 42-72% enhanced IL-2 production over vehicle controls when tested in a chicken T cell blast bioassay. Supplementation of chicken splenic T lymphocyte cultures with butylated hydroxyanisole (BHT) and butylated hydroxytoluene (BHA) also induced elevated levels of IL-2, suggesting a role for antioxidants in IL-2 production by avian splenic T lymphocytes. Supernatants from vitamin E succinate-supplemented murine EL-4 cells (0.1 microgram/mL vitamin E succinate) induced 52-75% increased levels of IL-2 when compared to supernatants from vehicle controls when tested using a murine, IL-2-dependent CTLL-2 bioassay. IL-2 production by EL-4 cells was not enhanced by treatments with BHT, BHA, or Trolox, suggesting that vitamin E succinate-induced IL-2 production by EL-4 cells may involve a mechanism other than antioxidant effects. Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells. The studies provide evidence that vitamin E succinate can directly potentiate either the production or release of IL-2 from avian splenocytes and murine EL-4 cells.

RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Publishing Authors By Initials

S Kidao,BG Sanders,K Kline,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biotechnology therapeutics

VOLUME: 4

Page Numbers: 117-32

Journal Abbreviation:

ISSN: 0898-2848

DAY: 19

MONTH: 11

YEAR: 1993

RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918082

RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Information

Substance Name: 6-hydroxy-2,5,7,8-tetramethylchroman-2-c

Registry Number: 56305-04-5

Grant and Affiliation Information for RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells.

AFFILIATION: University of Texas, Austin.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA45422

ACRONYM: CA

MEDLINETA: Biotechnol Ther

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