Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview.

Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview. Research Abstract Details 

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Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview. Abstract Text:

Istvan Vajtai, Arnold,Andreas Kappeler,Olivia Jeless,Anton Lukes,Luigi Mariani,Werner Paulus,

We report on clinicopathological findings in two cases of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT) occurring in females aged 16 years (Case 1) and 30 years (Case 2). Symptoms included vertigo, nausea, cerebellar ataxia, as well as headaches, and had been present for 4-months and 1 week, respectively. Magnetic resonance imaging (MRI) indicated a cerebellar-based tumor of 1.8cm (Case 1) and 5cm (Case 2) diameter each, bulging into the fourth ventricle. Case 2 involved a cyst-mural-nodule configuration. In both instances, the solid component appeared isointense on T(1) sequences, hyperintense in the T(2) mode, and enhanced moderately. Gross total resection was achieved via suboccipital craniotomy. However, functional recovery was disappointing in Case 1. On microscopy, both tumors comprised an admixture of low-grade astrocytoma interspersed with circular aggregates of synaptophysin-expressing round cells harboring oligodendrocyte-like nuclei. The astrocytic moiety in Case 1 was nondescript, and overtly pilocytic in Case 2. The architecture of neuronal elements variously consisted of neurocytic rosettes, of pseudorosettes centered on a capillary core, as well as of concentric ribbons along irregular lumina. Gangliocytic maturation, especially "floating neurons", or a corresponding immunoreactivity for neurofilament protein was absent. Neither of these populations exhibited atypia, mitotic activity, or a significant labeling for MIB-1. Cerebellar parenchyma included in the surgical specimen did not reveal any preexisting malformative anomaly. Despite sharing some overlapping histologic traits with dysembryoplastic neuroepithelial tumor (DNT), the presentation of RGNT with respect to both patient age and location is consistent enough for this lesion to be singled out as an autonomous entity.

Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview. Publishing Authors By Initials

I Vajtai,M Arnold,A Kappeler,O Jeless,A Lukes,L Mariani,W Paulus,

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Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pathology, research and practice

VOLUME: 203

Page Numbers: 613-9

Journal Abbreviation: Pathol. Res. Pract.

ISSN: 0344-0338

DAY: 24

MONTH: 07

YEAR: 2007

Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rosette-forming glioneuronal tumor of the fourth ventricle: Report of two cases with a differential diagnostic overview.

AFFILIATION: Section of Neuropathology, Institute of Pathology, University of Bern, Switzerland.

Country: Germany

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MEDLINETA: Pathol Res Pract

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