Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Research Abstract Details 

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Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Abstract Text:

Rachel D Mullen,Stephanie C Colvin,Chad S Hunter,Jesse J Savage,Emily C Walvoord,Amrit P S Bhangoo,Svetlana Ten,Johannes Weigel,Roland W ,Simon J Rhodes,

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Publishing Authors By Initials

RD Mullen,SC Colvin,CS Hunter,JJ Savage,EC Walvoord,AP Bhangoo,S Ten,J Weigel,RW ,SJ Rhodes,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular and cellular endocrinology

VOLUME: 265-266

Page Numbers: 190-5

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 8

MONTH: 01

YEAR: 2007

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Information

Number of References: 47

LANGUAGE: eng

NlmUniqueID: 7500844

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

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Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

AFFILIATION: Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202-5120, United States.

Country: Ireland

AGENCY: United States NICHD

GRANT: R01 HD042024-05

ACRONYM: HD

MEDLINETA: Mol Cell Endocrinol

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