Roles of the innate immune system in mammary gland remodeling during involution.

Roles of the innate immune system in mammary gland remodeling during involution. Research Abstract Details 

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Roles of the innate immune system in mammary gland remodeling during involution. Abstract Text:

Kamran Atabai,Dean Sheppard,Zena Werb,

Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocytes become the predominant cell type. The role of the immune system in this process has not been clearly defined. Professional phagocytes derived from the immune system can participate in the clearance of apoptotic and autophagic cells, the removal of residual milk components, and the prevention of mastitis during mammary gland involution. However, many of these functions can also be performed by non-professional phagocytes (e.g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution.

Roles of the innate immune system in mammary gland remodeling during involution. Publishing Authors By Initials

K Atabai,D Sheppard,Z Werb,

For similar cells: phagocytes research abstracts see: cells: phagocytes research

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Roles of the innate immune system in mammary gland remodeling during involution. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of mammary gland biology and neoplasia

VOLUME: 12

Page Numbers: 37-45

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ISSN: 1083-3021

DAY: 3

MONTH: Mar

YEAR: 2007

Roles of the innate immune system in mammary gland remodeling during involution. Information

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LANGUAGE: eng

NlmUniqueID: 9601804

Roles of the innate immune system in mammary gland remodeling during involution. Keywords Mesh Terms:

KEYWORDS: Phagocytes

MESH TERMS: immunology

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Grant and Affiliation Information for Roles of the innate immune system in mammary gland remodeling during involution.

AFFILIATION: Lung Biology Center, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143-2922, USA. Kamran.Atabai@UCSF.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL64353

ACRONYM: HL

MEDLINETA: J Mammary Gland Biol Neoplasia

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