Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release.

Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. Research Abstract Details 

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Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. Abstract Text:

Yuki Hashimotodani,Takako Ohno-Shosaku,Masahiko Watanabe,Masanobu Kano,Yuki Hashimotodani,Takako Ohno-Shosaku,Masahiko Watanabe,Masanobu Kano,Yuki Hashimotodani,Takako Ohno-Shosaku,Masahiko Watanabe,Masanobu Kano,

Endocannabinoids are released from postsynaptic neurons, activate presynaptic cannabinoid receptors and cause various forms of short-term and long-term synaptic plasticity throughout the brain. Using hippocampal and cerebellar neurons, we have revealed that endocannabinoid release can be induced through two different pathways. One is independent of phospholipase Cbeta (PLCbeta) and driven by Ca(2+) elevation alone (Ca(2+)-driven endocannabinoid release, CaER), and the other is PLCbeta-dependent and driven by activation of G(q/11)-coupled receptors (receptor-driven endocannabinoid release, RER). CaER is induced by activation of either voltage-gated Ca(2+) channels or NMDA receptors. RER is functional even at resting Ca(2+) levels (basal RER), but markedly enhanced by a small Ca(2+) elevation (Ca(2+)-assisted RER). In Ca(2+)-assisted RER, PLCbeta serves as a coincidence detector of receptor activation and Ca(2+) elevation. We have also demonstrated that Ca(2+)-assisted RER is essential for the endocannabinoid release triggered by synaptic activity. Our anatomical data show that a set of receptors and enzymes required for RER are well organized so that the excitatory input can trigger RER effectively. Certain forms of spike-timing-dependent plasticity (STDP) are reported to depend on endocannabinoid signalling. The NMDA receptor and PLCbeta might play key roles in the endocannabinoid-dependent forms of STDP as coincidence detectors with different timing dependences.

Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. Publishing Authors By Initials

Y Hashimotodani,T Ohno-Shosaku,M Watanabe,M Kano,Y Hashimotodani,T Ohno-Shosaku,M Watanabe,M Kano,Y Hashimotodani,T Ohno-Shosaku,M Watanabe,M Kano,

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Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of physiology

VOLUME: 584

Page Numbers: 373-80

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 0022-3751

DAY: 5

MONTH: 07

YEAR: 2007

Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release.

AFFILIATION: Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan. mkano@cns.med.osaka-u.ac.jp.

Country: England

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MEDLINETA: J Physiol

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