Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair.

Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Research Abstract Details 

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Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Abstract Text:

Chemotherapy agents induce apoptotic cell death and loss of cell proliferation in the intestinal crypt epithelium, resulting in intestinal mucosal damage called "mucositis". Small intestinal mucositis is characterized structurally by crypt loss and villus atrophy, and functionally by absorptive and barrier impairments. The increased use of chemotherapy in cancer treatment and the clinical importance of the intestinal mucositis as a common side effect have stimulated more active research into understanding the pathophysiology of intestinal mucositis and developing agents for preventing or treating this condition. Rodent studies have shown that, following the chemotherapy-induced initial apoptosis and loss of crypt cell proliferation, many different growth factors or their receptors are upregulated locally at the crypts, preceding or coinciding with the epithelial hyperproliferative repair response. Aiming to reduce crypt cell apoptotic sensitivity to cytotoxic chemotherapy and/or to enhance crypt epithelial proliferative repair, several exogenous growth factor treatments have been tested, either preclinically and/or clinically, and are showing promise for their efficacy or safety in preventing or treating chemotherapy-induced mucositis. These tested growth factors include keratinocyte growth factor, interleukin-11, transforming growth factor beta, milk-derived growth factor extract, macrophage/granulocyte colony stimulating factors, and glucagon-like peptide 2. Further research on the basic and discovery levels and subsequent translational studies are needed to understand more about chemotherapy-induced intestinal mucositis and to identify candidates of growth factors or other agents that will potentially prevent or treat chemotherapy-induced mucositis more effectively, specifically, safely, and practically in chemotherapy patients.

Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Publishing Authors By Initials

For similar digestive system: gastrointestinal tract: intestines: intestinal mucosa research abstracts see: digestive system: gastrointestinal tract: intestines: intestinal mucosa research

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Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 4

Page Numbers: 260-9

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Aug

YEAR: 2003

Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Information

Number of References: 114

LANGUAGE: eng

NlmUniqueID: 100960530

Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Keywords Mesh Terms:

KEYWORDS: Intestinal Mucosa

MESH TERMS: pathology

Chemical & Substance for Abstract: Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Information

Substance Name: Growth Substances

Registry Number: 0

Grant and Affiliation Information for Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair.

AFFILIATION: Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women's and Children's Hospital, North Adelaide 5006, Australia. cory.xian@adelaide.edu.au

Country: Netherlands

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MEDLINETA: Curr Pharm Biotechnol

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