Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis.

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Research Abstract Details 

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Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Abstract Text:

Takashi Ohno,Youichiro Hattori,Rie Komine,Takako Ae,Sumito Mizuguchi,Katsuharu Arai,Takeo Saeki,Tatsunori Suzuki,Kanako Hosono,Izumi Hayashi,Yoshio Oh-Hashi,Yukiko Kurihara,Hiroki Kurihara,Kikuko Amagase,Susumu Okabe,Katsunori Saigenji,Masataka Majima,Takashi Ohno,Youichiro Hattori,Rie Komine,Takako Ae,Sumito Mizuguchi,Katsuharu Arai,Takeo Saeki,Tatsunori Suzuki,Kanako Hosono,Izumi Hayashi,Yoshio Oh-Hashi,Yukiko Kurihara,Hiroki Kurihara,Kikuko Amagase,Susumu Okabe,Katsunori Saigenji,Masataka Majima,Takashi Ohno,Youichiro Hattori,Rie Komine,Takako Ae,Sumito Mizuguchi,Katsuharu Arai,Takeo Saeki,Tatsunori Suzuki,Kanako Hosono,Izumi Hayashi,Yoshio Oh-Hashi,Yukiko Kurihara,Hiroki Kurihara,Kikuko Amagase,Susumu Okabe,Katsunori Saigenji,Masataka Majima,

BACKGROUND & AIMS: The gastrointestinal tract is known to be rich in neural systems, among which afferent neurons are reported to exhibit protective actions. We tested whether an endogenous neuropeptide, calcitonin gene-related peptide (CGRP), can prevent gastric mucosal injury elicited by ethanol and enhance healing of acetic acid-induced ulcer using CGRP knockout mice (CGRP(-/-)). METHODS: The stomach was perfused with 1.6 mmol/L capsaicin or 1 mol/L NaCl, and gastric mucosal injury elicited by 50% ethanol was estimated. Levels of CGRP in the perfusate were determined by enzyme immunoassay. Gastric ulcers were induced by serosal application of absolute acetic acid. RESULTS: Capsaicin inhibited injured area dose-dependently. Fifty percent ethanol containing capsaicin immediately increased intragastric levels of CGRP in wild-type (WT) mice, although 50% ethanol alone did not. The protective action of capsaicin against ethanol was completely abolished in CGRP(-/-). Preperfusion with 1 mol/L NaCl increased CGRP release and reduced mucosal damage during ethanol perfusion. However, 1 mol/L NaCl was not effective in CGRP(-/-). Healing of ulcer elicited by acetic acid in CGRP(-/-) mice was markedly delayed, compared with that in WT. In WT, granulation tissues were formed at the base of ulcers, and substantial neovascularization was induced, whereas those were poor in CGRP(-/-). Expression of vascular endothelial growth factor was more markedly reduced in CGRP(-/-) than in WT. CONCLUSIONS: CGRP has a preventive action on gastric mucosal injury and a proangiogenic activity to enhance ulcer healing. These results indicate that the CGRP-dependent pathway is a good target for regulating gastric mucosal protection and maintaining gastric mucosal integrity.

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Publishing Authors By Initials

T Ohno,Y Hattori,R Komine,T Ae,S Mizuguchi,K Arai,T Saeki,T Suzuki,K Hosono,I Hayashi,Y Oh-Hashi,Y Kurihara,H Kurihara,K Amagase,S Okabe,K Saigenji,M Majima,T Ohno,Y Hattori,R Komine,T Ae,S Mizuguchi,K Arai,T Saeki,T Suzuki,K Hosono,I Hayashi,Y Oh-Hashi,Y Kurihara,H Kurihara,K Amagase,S Okabe,K Saigenji,M Majima,T Ohno,Y Hattori,R Komine,T Ae,S Mizuguchi,K Arai,T Saeki,T Suzuki,K Hosono,I Hayashi,Y Oh-Hashi,Y Kurihara,H Kurihara,K Amagase,S Okabe,K Saigenji,M Majima,

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Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gastroenterology

VOLUME: 134

Page Numbers: 215-25

Journal Abbreviation: Gastroenterology

ISSN: 1528-0012

DAY: 5

MONTH: 10

YEAR: 2007

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Country: United States

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MEDLINETA: Gastroenterology

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