Roles of BCCIP in chromosome stability and cytokinesis.

Roles of BCCIP in chromosome stability and cytokinesis. Research Abstract Details 

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Roles of BCCIP in chromosome stability and cytokinesis. Abstract Text:

X Meng,J Fan,Z Shen,

The BRCA2 gene is involved in recombinational DNA repair and cytokinesis. BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomic instability that contributes to tumorigenesis. Here, we show that downregulation of a BRCA2 interacting protein (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation. The BCCIP knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complete cytokinesis. Our data suggest an essential role of BCCIP in the maintenance of genomic integrity.

Roles of BCCIP in chromosome stability and cytokinesis. Publishing Authors By Initials

X Meng,J Fan,Z Shen,

For similar genetic processes: gene expression regulation: epigenesis, genetic: gene silencing: rna interference research abstracts see: genetic processes: gene expression regulation: epigenesis, genetic: gene silencing: rna interference research

PUBMED ID PMID:

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Roles of BCCIP in chromosome stability and cytokinesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Oncogene

VOLUME: 26

Page Numbers: 6253-60

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 23

MONTH: 04

YEAR: 2007

Roles of BCCIP in chromosome stability and cytokinesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

Roles of BCCIP in chromosome stability and cytokinesis. Keywords Mesh Terms:

KEYWORDS: RNA Interference

MESH TERMS: metabolism

Chemical & Substance for Abstract: Roles of BCCIP in chromosome stability and cytokinesis. Information

Substance Name: Nuclear Proteins

Registry Number: 0

Grant and Affiliation Information for Roles of BCCIP in chromosome stability and cytokinesis.

AFFILIATION: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Country: England

AGENCY: United States NIEHS

GRANT: ES08353

ACRONYM: ES

MEDLINETA: Oncogene

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