Roles for Drosophila mushroom body neurons in olfactory learning and memory.

Roles for Drosophila mushroom body neurons in olfactory learning and memory. Research Abstract Details 

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Roles for Drosophila mushroom body neurons in olfactory learning and memory. Abstract Text:

David-Benjamin G Akalal,Curtis F Wilson,Lin Zong,Nobuaki K Tanaka,Kei Ito,Ronald L Davis,

Olfactory learning assays in Drosophila have revealed that distinct brain structures known as mushroom bodies (MBs) are critical for the associative learning and memory of olfactory stimuli. However, the precise roles of the different neurons comprising the MBs are still under debate. The confusion surrounding the roles of the different neurons may be due, in part, to the use of different odors as conditioned stimuli in previous studies. We investigated the requirements for the different MB neurons, specifically the alpha/beta versus the gamma neurons, and whether olfactory learning is supported by different subsets of MB neurons irrespective of the odors used as conditioned stimuli. We expressed the rutabaga (rut)-encoded adenylyl cyclase in either the gamma or alpha/beta neurons and examined the effects on restoring olfactory associative learning and memory of rut mutant flies. We also expressed a temperature-sensitive shibire (shi) transgene in these neuron sets and examined the effects of disrupting synaptic vesicle recycling on Drosophila olfactory learning. Our results indicate that although we did not detect odor-pair-specific learning using GAL4 drivers that primarily express in gamma neurons, expression of the transgenes in a subset of alpha/beta neurons resulted in both odor-pair-specific rescue of the rut defect as well as odor-pair-specific disruption of learning using shi(ts1).

Roles for Drosophila mushroom body neurons in olfactory learning and memory. Publishing Authors By Initials

DB Akalal,CF Wilson,L Zong,NK Tanaka,K Ito,RL Davis,

For similar sensation: smell research abstracts see: sensation: smell research

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Roles for Drosophila mushroom body neurons in olfactory learning and memory. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Learning & memory (Cold Spring Harbor, N.Y.)

VOLUME: 13

Page Numbers: 659-68

Journal Abbreviation: Learn. Mem.

ISSN: 1072-0502

DAY: 15

MONTH: 09

YEAR: 2006

Roles for Drosophila mushroom body neurons in olfactory learning and memory. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9435678

Roles for Drosophila mushroom body neurons in olfactory learning and memory. Keywords Mesh Terms:

KEYWORDS: Smell

MESH TERMS: physiology

Chemical & Substance for Abstract: Roles for Drosophila mushroom body neurons in olfactory learning and memory. Information

Substance Name: rutabaga protein, Drosophila

Registry Number: EC 4.6.1.1

Grant and Affiliation Information for Roles for Drosophila mushroom body neurons in olfactory learning and memory.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. dakalal@bcm.tmc.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS19904

ACRONYM: NS

MEDLINETA: Learn Mem

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