Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits.

Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Research Abstract Details 

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Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Abstract Text:

To elucidate the contributions of renal, humoral, and arterial baroreceptor reflex components to salt-induced hypertension, we administered 10% NaCl intravenously for 10 days to sinoaortic-denervated rabbits with unilateral nephrectomy (n = 7), sinoaortic-denervated rabbits with intact kidneys (n = 7), and sham-operated sinoaortic-denervated rabbits with unilateral nephrectomy (n = 7). Serial changes in mean arterial pressure (MAP), heart rate, and blood pressure variability were recorded. In sinoaortic-denervated rabbits with unilateral nephrectomy, MAP increased significantly from 109 +/- 2 to 124 +/- 3 mm Hg (day 4) and remained elevated for the rest of the experiment. This elevation of MAP was accompanied by a reduction in the standard deviation of MAP, with significant elevations in plasma vasopressin, norepinephrine, and atrial natriuretic peptide concentrations and in sodium retention. In the other groups, there were no significant changes in these vasoactive hormones. In the sham-operated sinoaortic-denervated rabbits with unilateral nephrectomy, sodium retention was similar to that of sinoaortic-denervated rabbits with unilateral nephrectomy. Continuous infusion (1 microgram/kg/hr) of a V1 antagonist prevented the elevation of blood pressure and plasma norepinephrine, the accumulation of sodium, and the reduction of blood pressure lability, whereas a bolus injection (10 micrograms/kg) on day 4 reduced blood pressure from 128 +/- 3 to 115 +/- 2 mm Hg (p less than 0.005). These results imply that vasopressin plays a crucial role in the expression of salt-induced hypertension in rabbits with compromised baroreceptor and renal function.

Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Publishing Authors By Initials

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Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hypertension

VOLUME: 17

Page Numbers: 1085-91

Journal Abbreviation: Hypertension

ISSN: 0194-911X

DAY: 16

MONTH: Jun

YEAR: 1991

Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 7906255

Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Keywords Mesh Terms:

KEYWORDS: Vasopressins

MESH TERMS: physiology

Chemical & Substance for Abstract: Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

Grant and Affiliation Information for Role of vasopressin in salt-induced hypertension in baroreceptor-denervated uninephrectomized rabbits.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Hypertension

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