Role of urothelial nerve growth factor in human bladder function.

Role of urothelial nerve growth factor in human bladder function. Research Abstract Details 

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Role of urothelial nerve growth factor in human bladder function. Abstract Text:

Lori A Birder,Amanda Wolf-Johnston,Derek Griffiths,Neil M Resnick,

AIMS: To test whether nerve growth factor (NGF) concentration in human bladder urothelium/suburothelium is related to detrusor overactivity (DO), bladder sensation, detrusor contractility, or other aspects of lower urinary tract function. MATERIALS AND METHODS: Concentration of NGF was measured (using ELISA) in superficial bladder biopsies from 27 women (mean age 52 years, range 22-82) after comprehensive video-urodynamics and bladder diary. Approximately half (12/27) showed clear DO and half did not. RESULTS: There was no evidence for increased NGF concentration in subjects with DO (association negative by Mann-Whitney test, P = 0.23). NGF was not significantly associated with two measures of detrusor contractility (Spearman's r = -0.29, P = 0.17; r = -0.20, P = 0.33); nor with four measures inversely related to sensation: volume at strong desire to void and maximum capacity on cystometry (r = -0.13, P = 0.53; r = -0.23, P = 0.28), and maximum voided volume and mean daytime voided volume on bladder diary (r = -0.29, P = 0.16; r = -0.16, P = 0.44). It was significantly associated with 24-hr urine output on bladder diary (Spearman's r = -0.55, P = 0.004). CONCLUSIONS: Elevated NGF levels in human urothelium/suburothelium are not strongly associated with DO, detrusor contractility or increased bladder sensation. NGF levels are lower in subjects with higher 24-hr urine output. This observation is consistent with a role for NGF in an active process (trafficking) involved in bladder filling.

Role of urothelial nerve growth factor in human bladder function. Publishing Authors By Initials

LA Birder,A Wolf-Johnston,D Griffiths,NM Resnick,

For similar tissues: epithelium: urothelium research abstracts see: tissues: epithelium: urothelium research

PUBMED ID PMID:

MEDLINE DATE:

Role of urothelial nerve growth factor in human bladder function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurourology and urodynamics

VOLUME: 26

Page Numbers: 405-9

Journal Abbreviation:

ISSN: 0733-2467

DAY: 3

MONTH: 12

YEAR: 2007

Role of urothelial nerve growth factor in human bladder function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8303326

Role of urothelial nerve growth factor in human bladder function. Keywords Mesh Terms:

KEYWORDS: Urothelium

MESH TERMS: pathology

Chemical & Substance for Abstract: Role of urothelial nerve growth factor in human bladder function. Information

Substance Name: Nerve Growth Factor

Registry Number: 9061-61-4

Grant and Affiliation Information for Role of urothelial nerve growth factor in human bladder function.

AFFILIATION: Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01-DK54824

ACRONYM: DK

MEDLINETA: Neurourol Urodyn

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