Role of the transcription activator Ste12p as a repressor of PRY3 expression.

Role of the transcription activator Ste12p as a repressor of PRY3 expression. Research Abstract Details 

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Role of the transcription activator Ste12p as a repressor of PRY3 expression. Abstract Text:

Kellie S Bickel,David R Morris,

Mating pheromone represses synthesis of full-length PRY3 mRNA, and a new transcript appears simultaneously with its 5' terminus 452 nucleotides inside the open reading frame (ORF). Synthesis of this shorter transcript results from activation of a promoter within the PRY3 locus, and its production is concomitant with the rapid disappearance of the full-length transcript. Evidence is consistent with the pheromone-induced transcription factor Ste12p binding two pheromone response elements within the PRY3 promoter, directly impeding transcription of the full-length mRNA while simultaneously inducing initiation of the short transcript. This process depends on a TATA box within the PRY3 ORF. Expression of full-length PRY3 inhibited mating, while no disadvantage was detectable for cells unable to make the short transcript. Therefore, Ste12p is utilized as a repressor of full-length PRY3 transcription, ensuring efficient mating. There is no evidence that production of the short PRY3 transcript is anything more than an adventitious by-product of this mechanism. It is possible that cryptic binding sites for transcriptional activators may occur frequently within genomes and have the potential of evolving for rapid, gene-specific repression by mechanisms analogous to PRY3. PRY3 regulation provides a model for the coordination of both inductive and repressive activities within a regulatory network.

Role of the transcription activator Ste12p as a repressor of PRY3 expression. Publishing Authors By Initials

KS Bickel,DR Morris,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Role of the transcription activator Ste12p as a repressor of PRY3 expression. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular and cellular biology

VOLUME: 26

Page Numbers: 7901-12

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 28

MONTH: 08

YEAR: 2006

Role of the transcription activator Ste12p as a repressor of PRY3 expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109087

Role of the transcription activator Ste12p as a repressor of PRY3 expression. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of the transcription activator Ste12p as a repressor of PRY3 expression. Information

Substance Name: RNA Polymerase II

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Role of the transcription activator Ste12p as a repressor of PRY3 expression.

AFFILIATION: Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32 GM07270

ACRONYM: GM

MEDLINETA: Mol Cell Biol

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