Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Research Abstract Details 

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Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Abstract Text:

Jianguo Xu,Ana Mora,Hyunsuk Shim,Arlene Stecenko,Kenneth L Brigham,Mauricio Rojas,

Stromal cell-derived factor-1 (SDF-1) participates in mobilizing bone marrow-derived stem cells, via its receptor CXCR4. We studied the role of the SDF-1/CXCR4 axis in a rodent model of bleomycin-induced lung injury in C57BL/6 wild-type and matrix metalloproteinase (MMP)-9 knockout mice. After intratracheal instillation of bleomycin, SDF-1 levels in serum and bronchial alveolar lavage fluid increased. These changes were accompanied by increased numbers of CXCR4(+) cells in the lung and a decrease in a population of CXCR4(+) cells in the bone marrow that did not occur in MMP-9(-)/(-) mice. Both SDF-1 and lung lysates from bleomycin-treated mice induced migration of bone marrow-derived stem cells in vitro that was blocked by a CXCR4 antagonist, TN14003. Treatment of mice with TN14003 with bleomycin-induced lung injury significantly attenuated lung fibrosis. Lung tissue from patients with idiopathic pulmonary fibrosis had higher numbers of cells expressing both SDF-1 and CXCR4 than did normal lungs. Our data suggest that the SDF-1/CXCR4 axis is important in the complex sequence of events triggered by bleomycin exposure that eventuates in lung repair. SDF-1 participates in mobilizing bone marrow-derived stem cells, via its receptor CXCR4.

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Publishing Authors By Initials

J Xu,A Mora,H Shim,A Stecenko,KL Brigham,M Rojas,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, chemokine: receptors, cxcr: receptors, cxcr4 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, chemokine: receptors, cxcr: receptors, cxcr4 research

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MEDLINE DATE:

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of respiratory cell and molecular

VOLUME: 37

Page Numbers: 291-9

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1044-1549

DAY: 26

MONTH: 04

YEAR: 2007

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8917225

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Keywords Mesh Terms:

KEYWORDS: Receptors, CXCR4

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Information

Substance Name: Matrix Metalloproteinase 9

Registry Number: EC 3.4.24.35

Grant and Affiliation Information for Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

AFFILIATION: Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL080284-01

ACRONYM: HL

MEDLINETA: Am J Respir Cell Mol Biol

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