Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism.

Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Research Abstract Details 

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Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Abstract Text:

This study was conducted to examine whether the renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy without involving the sympathetic nervous system. Sprague-Dawley rats were divided into control-innervated, control-denervated, hyperthyroid-innervated, and hyperthyroid-denervated groups using intraperitoneal injections of thyroxine and 6-hydroxydopamine. After 8 wk, the heart-to-body weight ratio increased in hyperthyroid groups (63%), and this increase was only partially inhibited by sympathetic denervation. Radioimmunoassays and reverse transcription-polymerase chain reaction revealed increased cardiac levels of renin (33%) and angiotensin II (53%) and enhanced cardiac expression of renin mRNA (225%) in the hyperthyroid groups. These increases were unaffected by sympathetic denervation or 24-h bilateral nephrectomy. In addition, losartan and nicardipine decreased systolic blood pressure to the same extent, but only losartan caused regression of thyroxine-induced cardiac hypertrophy. These results suggest that thyroid hormone activates the cardiac renin-angiotensin system without involving the sympathetic nervous system or the circulating renin-angiotensin system; the activated renin-angiotensin system contributes to cardiac hypertrophy in hyperthyroidism.

Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Publishing Authors By Initials

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Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of physiology

VOLUME: 273

Page Numbers: H593-9

Journal Abbreviation: Am. J. Physiol.

ISSN: 0002-9513

DAY: 14

MONTH: Aug

YEAR: 1997

Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370511

Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Keywords Mesh Terms:

KEYWORDS: Thyroxine

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. Information

Substance Name: Thyroxine

Registry Number: 7488-70-2

Grant and Affiliation Information for Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: UNITED STATES

AGENCY: United States NIDDK

GRANT: R01 DK072408-01A1

ACRONYM: DK

MEDLINETA: Am J Physiol

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