Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context.

Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Research Abstract Details 

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Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Abstract Text:

Erina Hara,Lubica Kubikova,Neal A Hessler,Erich D Jarvis,

In a well-studied model of social behaviour, male zebra finches sing directed song to court females and undirected song, used possibly for practice or advertisement. Although the two song types are similar, the level of neural activity and expression of the immediate early gene egr-1 are higher during undirected than during directed singing in the lateral part of the basal ganglia song nucleus AreaX (LAreaX) and its efferent pallial song nuclei lateral magnocellular nucleus of the anterior nidopallium (LMAN) and the robust nucleus of the arcopallium (RA). As social interactions are dependent on brain motivation systems, here we test the hypothesis that the midbrain ventral tegmental area-substantia nigra pars compacta (VTA-SNc) complex, which provides a strong dopaminergic input to LAreaX, is a source of this modulation. Using egr-1 expression, we show that GABAergic interneurons in VTA-SNc are more active during directed courtship singing than during undirected singing. We also found that unilateral removal of VTA-SNc input reduced singing-dependent gene expression in ipsilateral LAreaX during both social contexts but it did not eliminate social context differences in LAreaX. In contrast, such lesions reduced and eliminated the social context differences in efferent nuclei LMAN and RA, respectively. These results suggest that VTA-SNc is not solely responsible for the social context gene regulation in LAreaX, but that VTA-SNc input to LAreaX enhances the singing-regulated gene expression in this nucleus and, either through LAreaX or through direct projections to LMAN and RA, VTA-SNc is necessary for context-dependent gene regulation in these efferent nuclei.

Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Publishing Authors By Initials

E Hara,L Kubikova,NA Hessler,ED Jarvis,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 3406-16

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 3

MONTH: Jun

YEAR: 2007

Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context.

AFFILIATION: Laboratory for Vocal Behaviour Mechanisms, RIKEN Brain Science Institute, Wako-shi, Japan.

Country: France

AGENCY: United States NIMH

GRANT: R01MH62083

ACRONYM: MH

MEDLINETA: Eur J Neurosci

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