Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Research Abstract Details 

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Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Abstract Text:

Yan Zhu,Tao Yu,Xiao-Chun Zhang,Takashi Nagasawa,Jane Y Wu,Yi Rao,

Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells.

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Publishing Authors By Initials

Y Zhu,T Yu,XC Zhang,T Nagasawa,JY Wu,Y Rao,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature neuroscience

VOLUME: 5

Page Numbers: 719-20

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 19

MONTH: Aug

YEAR: 2002

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9809671

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: drug effects

Chemical & Substance for Abstract: Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Information

Substance Name: Cxcl12 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.

AFFILIATION: Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM070967-02

ACRONYM: GM

MEDLINETA: Nat Neurosci

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