Role of TGF-beta family in osteoclastogenesis induced by RANKL.

Role of TGF-beta family in osteoclastogenesis induced by RANKL. Research Abstract Details 

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Role of TGF-beta family in osteoclastogenesis induced by RANKL. Abstract Text:

Takeyoshi Koseki,Ying Gao,Nobuo Okahashi,Yoshiyuki Murase,Toshiyuki Tsujisawa,Tsuyoshi Sato,Kenji Yamato,Tatsuji Nishihara,

Recent studies have revealed that both transforming growth factor-beta (TGF-beta) and activin A play pivotal roles in osteoclastogenesis. In this report, we show that the effect of TGF-beta family members, TGF-beta1 and activin A, but not BMP-2, enhance multinucleated osteoclast-like cell (OCL) formation induced by receptor activator of NF-kappaB ligand (RANKL) in isolated bone marrow macrophages and monocytic cell line, RAW264.7. TGF-beta1 and activin A caused the growth suppression and concomitant expression of tartrate-resistant acid phosphatase (TRAP) and c-Src, without inducing syncytium formation or increasing the survival rate in RAW264.7 cells. Although TGF-beta1 and activin A had no effect on NF-kappaB and JNK activities, these factors enhanced the expression of JunB, a component of the AP-1 transcriptional complex. These results suggest that TGF-beta1 and activin A may function as commitment factors in osteoclastic differentiation, not as a crucial component for terminal differentiation to form multinucleated OCLs nor in OCL survival.

Role of TGF-beta family in osteoclastogenesis induced by RANKL. Publishing Authors By Initials

T Koseki,Y Gao,N Okahashi,Y Murase,T Tsujisawa,T Sato,K Yamato,T Nishihara,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

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Role of TGF-beta family in osteoclastogenesis induced by RANKL. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular signalling

VOLUME: 14

Page Numbers: 31-6

Journal Abbreviation: Cell. Signal.

ISSN: 0898-6568

DAY: 19

MONTH: Jan

YEAR: 2002

Role of TGF-beta family in osteoclastogenesis induced by RANKL. Information

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LANGUAGE: eng

NlmUniqueID: 8904683

Role of TGF-beta family in osteoclastogenesis induced by RANKL. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: physiology

Chemical & Substance for Abstract: Role of TGF-beta family in osteoclastogenesis induced by RANKL. Information

Substance Name: Acid Phosphatase

Registry Number: EC 3.1.3.2

Grant and Affiliation Information for Role of TGF-beta family in osteoclastogenesis induced by RANKL.

AFFILIATION: Department of Oral Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.

Country: England

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MEDLINETA: Cell Signal

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