Role of test activity in ethanol-induced disruption of place preference expression in mice.

Role of test activity in ethanol-induced disruption of place preference expression in mice. Research Abstract Details 

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Role of test activity in ethanol-induced disruption of place preference expression in mice. Abstract Text:

Christina M Gremel,Christopher L Cunningham,

RATIONALE: Reduced expression of a drug-induced conditioned place preference (CPP) may reflect a decrease in the drug's conditioned rewarding effects. However, CPP is also open to disruption by processes unrelated to the underlying motivation. In unpublished studies, we previously observed that ethanol pretreatment before testing disrupted expression of ethanol-induced CPP in DBA/2J mice. We hypothesized that this interference effect was due to large ethanol-induced increases in activity. OBJECTIVE: The present studies were designed to examine the relationship between test activity and expression of ethanol-induced CPP both in the presence and absence of ethanol. To assess the generality of this relationship, we examined these effects both in DBA/2J (which are highly activated by ethanol) and in NZB/B1NJ mice (which show similar CPP, but less ethanol-induced activation). MATERIALS AND METHODS: In separate experiments, inbred mice from each strain underwent ethanol (2 g/kg) place conditioning. Saline or ethanol was then administered immediately before the test. RESULTS: Ethanol, given immediately before the test, blocked the expression of ethanol CPP in DBA/2J, but not in NZB/B1NJ mice. Moreover, ethanol significantly increased test activity levels in DBA/2J and to a much lesser degree in NZB/B1NJ mice. Correlation analyses showed an inverse phenotypic relationship between preference and test activity, reflecting stronger preferences in less active mice. CONCLUSIONS: Disruption of ethanol-CPP observed in DBA/2J mice may be a consequence of high ethanol-induced activity levels. More generally, these studies suggest that competing behaviors can affect expression of a drug-induced CPP independent of affecting the conditioned rewarding effects of the drug.

Role of test activity in ethanol-induced disruption of place preference expression in mice. Publishing Authors By Initials

CM Gremel,CL Cunningham,

For similar psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research abstracts see: psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research

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MEDLINE DATE:

Role of test activity in ethanol-induced disruption of place preference expression in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 191

Page Numbers: 195-202

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 10

MONTH: 01

YEAR: 2007

Role of test activity in ethanol-induced disruption of place preference expression in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Role of test activity in ethanol-induced disruption of place preference expression in mice. Keywords Mesh Terms:

KEYWORDS: Reward

MESH TERMS: drug effects

Chemical & Substance for Abstract: Role of test activity in ethanol-induced disruption of place preference expression in mice. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Role of test activity in ethanol-induced disruption of place preference expression in mice.

AFFILIATION: Department of Behavioral Neuroscience, L470, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.

Country: Germany

AGENCY: United States NIAAA

GRANT: AA016041

ACRONYM: AA

MEDLINETA: Psychopharmacology (Berl)

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