Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial.

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Abstract Text:

Sriparna Basu,Ashok Kumar,B D Bhatia,K Satya,T B Singh,Sriparna Basu,Ashok Kumar,B D Bhatia,K Satya,T B Singh,

Background: Meconium aspiration syndrome (MAS) is one of the major causes of severe respiratory distress in the newborn and there is no uniform protocol of management after the development of MAS. Objective: The objective of the study was to determine whether systemic and inhalational steroid therapy can alter the clinical course of MAS and improve the outcome without causing any serious adverse effects. Methods: A randomized controlled trial was conducted in three groups of MAS over a period of 1 year. Group A (n = 33) served as controls, Group B (n = 34) received systemic methyl prednisolone and Group C (n = 32) received nebulized budesonide both for a period of 7 days starting after 24 h of age. Details of clinical progress were noted during the hospital stay. Follow up for a minimum period of 3 months was done in all. Data were analysed by SPSS 10 software. Student's t and ANOVA were used to assess statistical significance. Results: Patient profile was similar in all the three groups. Period of oxygen dependency and duration of hospital stay was significantly less in the steroid treated groups. Similarly full enteral feeding and radiological clearance of chest could be achieved earlier in groups B and C. No difference between the steroid treated groups could be appreciated by Student's Newman Kuel (SNK) test. Development of sepsis was similar in all the groups and no serious adverse effects were noted in steroid treated groups. Conclusion: Steroids are effective in the management of MAS and route of administration does not have a bearing on the efficacy.

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Publishing Authors By Initials

S Basu,A Kumar,BD Bhatia,K Satya,TB Singh,S Basu,A Kumar,BD Bhatia,K Satya,TB Singh,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of tropical pediatrics

VOLUME: 53

Page Numbers: 331-7

Journal Abbreviation: J. Trop. Pediatr.

ISSN: 0142-6338

DAY: 29

MONTH: 05

YEAR: 2007

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8010948

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial.

AFFILIATION: Division of Neonatology and Division of Biostatistics, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Trop Pediatr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of steroids on the clinical course and outcome of meconium aspiration syndrome a randomized controlled trial Related Publications

• A definition of the breeding season of Pool Dorset ewes.
• A shift from significance test to hypothesis test through power analysis in medical research.
• Bio-histopathological studies of endometrium in repeat breeding buffaloes (Bubalus bubalis).
• Challenging and Changing Gender Attitudes among Young Men in Mumbai, India.
• Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2.
• ERK/MAPK pathway regulates GABAA receptors.
• Effect of adenotonsillitis on peak exploratory flow rate in children.
• Effects of bull and heparin and sperm concentrations on in vitro fertilization of buffalo (Bubalus bubalis ) oocytes matured in vitro.
• Efficacy of the Hamilton Thorn Motility Analyzer (HTM-2030) for the evaluation of bovine semen.
• Embryo transfer as a means of controlling the transmission of viral infections. XIII. Failure to transmit foot-and-mouth disease virus through the transfer of embryos from viremic donors.
• Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway.
• GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions.
• How much canola or cottonseed meals can be used for commercial chicken meat production.
• In patients with mild hypertension, does exercise and a gradual rather than abrupt increase in fatty acid and salt intake cause less rise in cardiovascular risk factors?
• In vitro maturation and fertilization of buffalo oocytes (Bubalus bubalis ): Effects of media, hormones and sera.
• Integrated preconcentration SDS-PAGE of proteins in microchips using photopatterned cross-linked polyacrylamide gels.
• Interaction of maternal protein and carbon monoxide on pup mortality in mice: implications for global infant mortality.
• Mitochondria as targets for detection and treatment of cancer.
• On-chip native gel electrophoresis-based immunoassays for tetanus antibody and toxin.
• Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.
• Plasma alpha-tocopherol profiles in sheep after oral administration of dl-alpha-tocopheryl acetate and d-alpha-tocopheryl succinate.
• Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized, double-blind, placebo-controlled study.
• Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.
• Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer.
• Responses of different doses of prostaglandin F(2) alpha on estrus induction, fertility and progesterone levels in subestrous buffaloes.
• Seasonal variation in freezability of buffalo semen.
• Steroid receptor coactivator AIB1 in endometrial carcinoma, hyperplasia and normal endometrium: Correlation with clinicopathologic parameters and biomarkers.
• The mental health challenge in Sri Lanka from working within the disaster area.
• Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.
• Variation in angiotensin-converting enzyme activity in the testes of prepubertal, pubertal and adult cockerels.