Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.

Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Research Abstract Details 

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Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Abstract Text:

Jin Y Ro,Jongseok Lee,Norman F Capra,Youping Zhang,Jin Y Ro,Jongseok Lee,Norman F Capra,Youping Zhang,

Nitric oxide (NO) produces its effects by activating soluble guanylate cyclase (sGC). In the present study, we investigated the potential role of sGC in the subnucleus caudalis (Vc) in mediating masseter hypersensitivity under acute inflammatory condition in male Sprague-Dawley rats. First, our Western blot analysis revealed that sGC protein is reliably detected in the Vc. Subsequent immunohistochemical studies demonstrated that neuronal cell bodies in the superficial laminae of the Vc positively stained for sGC. Astrocytes in deeper lamina of the Vc also showed sGC immunoreactivity. We then tested whether intrathecal administration of sGC inhibitors, methylene blue (MB), and ODQ, in the Vc, attenuates masseter hypersensitivity induced by intramuscular injection of capsaicin. Intrathecal MB or ODQ significantly blocked the capsaicin-induced reduction of mechanical threshold to noxious stimulation of the masseter. These data indicate that the NO-sGC pathway in the Vc is involved in mediating orofacial muscle hypersensitivity under acute inflammatory conditions.

Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Publishing Authors By Initials

JY Ro,J Lee,NF Capra,Y Zhang,JY Ro,J Lee,NF Capra,Y Zhang,

For similar nervous system: central nervous system: brain: brain stem: trigeminal nuclei: trigeminal nucleus, spinal: trigeminal caudal nucleus research abstracts see: nervous system: central nervous system: brain: brain stem: trigeminal nuclei: trigeminal nucleus, spinal: trigeminal caudal nucleus research

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Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1184

Page Numbers: 141-8

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 12

MONTH: 10

YEAR: 2007

Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Keywords Mesh Terms:

KEYWORDS: Trigeminal Caudal Nucleus

MESH TERMS: enzymology

Chemical & Substance for Abstract: Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity. Information

Substance Name: soluble guanylyl cyclase

Registry Number: EC 4.6.1.2

Grant and Affiliation Information for Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.

AFFILIATION: Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Baltimore, School of Dentistry, Baltimore, MD 21201, USA. jro@umaryland.edu

Country: Netherlands

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MEDLINETA: Brain Res

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