[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone]

[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Research Abstract Details 

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[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Abstract Text:

Gang Chen,Shi-Jie Zhao,Guang-Yan Yu,hui-Xing Wang,

OBJECTIVE: To evaluate the bone regenerative potential of recombinant human bone morphogenetic protein 2(rhBMP-2)/collagen on adult rat calvarial bone. METHODS: A tight subperiosteal pocket was produced under both sides of the temporal muscle in rats. rhBMP-2/collagen was implanted in one side and collagen alone was implanted in the other side as control. The rats were sacrificed 2, 4 and 8 weeks after operation. The specimen was harvested and examined histologically. For morphometric analysis, the thickness of the temporal bone of both sides was measured and compared. RESULTS: The rhBMP-2/collagen onlay implant resulted in active bone formation and the augmented bone was connected directly with the original bone, whereas the collagen alone resulted in neither bone nor cartilage production. The ossification process in the rhBMP-2/collagen occurred directly through bone formation, similar to intramembranous ossification. CONCLUSION: rhBMP-2/collagen is an effective material as a biological onlay implant.

[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Publishing Authors By Initials

G Chen,SJ Zhao,GY Yu,X Wang,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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MEDLINE DATE:

[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhonggu

VOLUME: 16

Page Numbers: 89-92

Journal Abbreviation:

ISSN: 1002-1892

DAY: 19

MONTH: Mar

YEAR: 2002

[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9425194

[Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: surgery

Chemical & Substance for Abstract: [Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone] Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for [Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone]

AFFILIATION: Department of Stomatology, Shenzhen Central Hospital, Shenzhen, Guangdong, P. R. China 518036. chg0425@sian.com.cn

Country: China

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MEDLINETA: Zhongguo Xiu Fu Chong Jian Wai

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