Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate.

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Research Abstract Details 

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Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Abstract Text:

Young-Hwa Kang,Eunmyong Lee,Moon-Kyung Choi,Ja-Lok Ku,So Hee Kim,Yong-Geun Park,Soo-Jeong Lim,

Alpha-tocopheryl succinate (TOS), a vitamin E analog, is a promising anticancer agent due to its abilities to inhibit proliferation and to induce apoptosis in a variety of human malignant cell lines, while being relatively less active toward normal cells. However, the molecular mechanisms underlying the apoptotic effects of TOS are not precisely understood. Reports that TOS can generate reactive oxygen species (ROS) prompted us to investigate the role of ROS in TOS-induced apoptosis in cancer cells. We found that the human lung cancer A549 and H460 cell lines were much more sensitive to TOS-induced apoptosis than the human glioblastoma T98G and U87MG cell lines. Our data suggested that the differential TOS sensitivity was not caused by differences in the uptake and retention of TOS between TOS-sensitive and -resistant cancer cells. The differential ability of cancer cells to generate ROS in response to TOS appears to be an important factor in determining the susceptibility of cells to TOS-induced apoptosis. Our results further suggest that TOS-induced generation of ROS is involved in caspase-independent apoptosis. Taken together, our findings suggest an important role of ROS generation in TOS-induced, caspase-independent apoptosis of cancer cells.

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Publishing Authors By Initials

YH Kang,E Lee,MK Choi,JL Ku,SH Kim,YG Park,SJ Lim,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of cancer. Journal internati

VOLUME: 112

Page Numbers: 385-92

Journal Abbreviation: Int. J. Cancer

ISSN: 0020-7136

DAY: 10

MONTH: Nov

YEAR: 2004

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Information

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LANGUAGE: eng

NlmUniqueID: 42124

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate.

AFFILIATION: Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea.

Country: United States

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MEDLINETA: Int J Cancer

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