Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice.

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Abstract Text:

Jeong-Hoon Joo,Young Jae Lee,Gustavo C Munguba,Sean Park,Timothy J Taxter,Mohamed Y Elsagga,Moira R Jackson,S Paul Oh,Stephen P Sugrue,

Previous in vitro studies have indicated multiple and varied roles of Pinin (PNN); however, its in vivo role has remained unclear. Here, we report generation of null, hypomorphic, and conditional Pnn alleles in mice. We found that insertion of neomycin-resistance cassette into intron 8 of Pnn resulted in knockdown of Pnn, which allowed Pnn hypomorphic embryos to pass peri-implantation lethality. These mice are lethal at perinatal stages and exhibit defects in the cardiac outflow tract, palate, dorsal dermis, and axial skeleton. Since Wnt/beta-catenin signaling has been shown to play pivotal roles in development of all tissues affected by Pnn hypomorphism, we speculated that Pnn may affect Wnt/beta-catenin signaling. Supporting this view, we demonstrate abnormal activities of Tcf/Lef transcription factors, and alterations in beta-catenin level in multiple Pnn hypomorphic tissues. Taken together, the data suggest that Pnn plays important roles during mouse development through its involvement in regulation of Tcf/Lef activity.

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Publishing Authors By Initials

JH Joo,YJ Lee,GC Munguba,S Park,TJ Taxter,MY Elsagga,MR Jackson,SP Oh,SP Sugrue,

For similar proteins: armadillo domain proteins: beta catenin research abstracts see: proteins: armadillo domain proteins: beta catenin research

PUBMED ID PMID:

MEDLINE DATE:

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 2147-58

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 28

MONTH: Aug

YEAR: 2007

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Keywords Mesh Terms:

KEYWORDS: beta Catenin

MESH TERMS: analysis

Chemical & Substance for Abstract: Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Information

Substance Name: beta Catenin

Registry Number: 0

Grant and Affiliation Information for Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice.

AFFILIATION: Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY007883

ACRONYM: EY

MEDLINETA: Dev Dyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice Related Publications

• "Renal dysfunction in trauma: even a little costs a lot".
• Cell system integration (CSI) trauma.
• Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
• Decompression in abdominal compartment syndrome: how early is early?
• Human metapneumovirus in children, singapore.
• Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice.
• The RSV F and G glycoproteins interact to form a complex on the surface of infected cells.