Role of osteopontin in neutrophil function.

Role of osteopontin in neutrophil function. Research Abstract Details 

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Role of osteopontin in neutrophil function. Abstract Text:

Adeline Koh,Andre Paes Batista da Silva,Anil K Bansal,Manju Bansal,Chunxiang Sun,Hyejin Lee,Michael Glogauer,Jaro Sodek,Ron Zohar,Adeline Koh,Andre Paes Batista da Silva,Anil K Bansal,Manju Bansal,Chunxiang Sun,Hyejin Lee,Michael Glogauer,Jaro Sodek,Ron Zohar,

Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased myeloperoxidase activity. The objective of this investigation therefore was to determine the importance of OPN expression in neutrophil function. Although, in contrast to macrophages, neutrophils expressed low levels of OPN with little or no association with the CD44 receptor, intraperitoneal recruitment of neutrophils in OPN-null mice was impaired in response to sodium periodate. The importance of exogenous OPN for neutrophil recruitment was demonstrated by a robust increase in peritoneal infiltration of PMNs in response to injections of native or recombinant OPN. In vitro, OPN(-/-) neutrophils exhibited reduced chemokinesis and chemotaxis towards N-formyl methionyl leucyl phenylalanine (fMLP), reflecting a reduction in migration speed and polarization. Exogenous OPN, which was chemotactic for the neutrophils, rescued the defects in polarization and migration speed of the OPN(-/-) neutrophils. In contrast, the defensive and cytocidal activities of OPN(-/-) neutrophils, measured by assays for phagocytosis, generation of reactive oxygen species, cytokine production and matrix metalloproteinase-9, were not impaired. These studies demonstrate that, while exogenous OPN may be important for the recruitment and migration of neutrophils, expression of OPN by neutrophils is not required for their destructive capabilities.

Role of osteopontin in neutrophil function. Publishing Authors By Initials

A Koh,AP da Silva,AK Bansal,M Bansal,C Sun,H Lee,M Glogauer,J Sodek,R Zohar,A Koh,AP da Silva,AK Bansal,M Bansal,C Sun,H Lee,M Glogauer,J Sodek,R Zohar,

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Role of osteopontin in neutrophil function. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology

VOLUME: 122

Page Numbers: 466-75

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ISSN: 1365-2567

DAY: 3

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 374672

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AFFILIATION: CIHR Group in Matrix Dynamics, Faculty of Dentistry, Department of Biochemistry, University of Toronto, Toronto, ONT, Canada.

Country: England

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MEDLINETA: Immunology

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