Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Research Abstract Details 

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Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Abstract Text:

Yasuhiro Kaiho,Izumi Kamo,Michael B Chancellor,Yoichi Arai,William C de Groat,Naoki Yoshimura,

To clarify the role of noradrenergic pathways in preventing stress urinary incontinence (SUI) during sneezing, we investigated the effect of the norepinephrine reuptake inhibitor nisoxetine and alpha-adrenoceptor antagonists phentolamine (nonspecific blocker) and prazosin (alpha(1)-receptor-selective blocker) on the neurally evoked urethral continence reflex induced by sneezing in rats. The amplitude of urethral pressure responses during sneezing (A-URS), urethral baseline pressure (UBP) at the midurethra, and sneeze-induced leak point pressure (S-LPP) were measured in normal female adult rats and rats with SUI induced by vaginal distention (VD). In normal rats, intrathecal (it) phentolamine (0.02 nmol) and prazosin (0.02 nmol) decreased A-URS by 11.9 and 15.7%, respectively, without affecting UBP. In both normal and VD rats, intravenous (iv) application of nisoxetine (1 mg/kg) increased A-URS by 17.2 and 18.3% and UBP by 23.7 and 32.7%, respectively. Phentolamine or prazosin (both it) eliminated nisoxetine-induced increases in A-URS, but not the increases in UBP, which were, however, suppressed by iv phentolamine (5 mg/kg) or prazosin (1 mg/kg). Sneezing induced fluid leakage from the urethral orifice in VD rats, but not in normal rats. In VD rats, S-LPP was increased by 30.2% by iv nisoxetine. Application of phentolamine and prazosin (both it) decreased S-LPP by 15.7 and 20.6%, respectively, and nisoxetine induced increases in S-LPP to 13.2 and 12.3%, respectively. These results indicate that activation of the noradrenergic system by a norepinephrine reuptake inhibitor can prevent SUI via alpha(1-)adrenoceptors by enhancing the sneeze-induced active urethral closure mechanism at the spinal level and augmenting UBP at the periphery.

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Publishing Authors By Initials

Y Kaiho,I Kamo,MB Chancellor,Y Arai,WC de Groat,N Yoshimura,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F639-46

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 17

MONTH: 10

YEAR: 2006

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: physiology

Chemical & Substance for Abstract: Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Information

Substance Name: nisoxetine

Registry Number: 57226-61-6

Grant and Affiliation Information for Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.

AFFILIATION: Dept. of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK-067226

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

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