Role of nanotechnology in targeted drug delivery and imaging: a concise review.

Role of nanotechnology in targeted drug delivery and imaging: a concise review. Research Abstract Details 

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Role of nanotechnology in targeted drug delivery and imaging: a concise review. Abstract Text:

Otilia M Koo,Israel Rubinstein,Hayat Onyuksel,

The use of nanotechnology in drug delivery and imaging in vivo is a rapidly expanding field. The emphases of this review are on biophysical attributes of the drug delivery and imaging platforms as well as the biological aspects that enable targeting of these platforms to injured and diseased tissues and cells. The principles of passive and active targeting of nanosized carriers to inflamed and cancerous tissues with increased vascular leakiness, overexpression of specific epitopes, and cellular uptake of these nanoscale systems are discussed. Preparation methods-properties of nanoscale systems including liposomes, micelles, emulsions, nanoparticulates, and dendrimer nanocomposites, and clinical indications are outlined separately for drug delivery and imaging in vivo. Taken together, these relatively new and exciting data indicate that the future of nanomedicine is very promising, and that additional preclinical and clinical studies in relevant animal models and disease states, as well as long-term toxicity studies, should be conducted beyond the "proof-of-concept" stage. Large-scale manufacturing and costs of nanomedicines are also important issues to be addressed during development for clinical indications.

Role of nanotechnology in targeted drug delivery and imaging: a concise review. Publishing Authors By Initials

OM Koo,I Rubinstein,H Onyuksel,

For similar cells: phagocytes research abstracts see: cells: phagocytes research

PUBMED ID PMID:

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Role of nanotechnology in targeted drug delivery and imaging: a concise review. Journal Published:

PUBLICATION TYPE: Review

Journal: Nanomedicine : nanotechnology, biology, and medici

VOLUME: 1

Page Numbers: 193-212

Journal Abbreviation:

ISSN: 1549-9642

DAY: 3

MONTH: Sep

YEAR: 2005

Role of nanotechnology in targeted drug delivery and imaging: a concise review. Information

Number of References: 212

LANGUAGE: eng

NlmUniqueID: 101233142

Role of nanotechnology in targeted drug delivery and imaging: a concise review. Keywords Mesh Terms:

KEYWORDS: Phagocytes

MESH TERMS: methods

Chemical & Substance for Abstract: Role of nanotechnology in targeted drug delivery and imaging: a concise review. Information

Substance Name: Ligands

Registry Number: 0

Grant and Affiliation Information for Role of nanotechnology in targeted drug delivery and imaging: a concise review.

AFFILIATION: Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60612-7231, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL72323

ACRONYM: HL

MEDLINETA: Nanomedicine

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