Role of myokines in exercise and metabolism.

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Role of myokines in exercise and metabolism. Abstract Text:

Bente Klarlund Pedersen, ,Anders R Nielsen,Christian P Fischer,Bente Klarlund Pedersen, ,Anders R Nielsen,Christian P Fischer,

During the past 20 yr, it has been well documented that exercise has a profound effect on the immune system. With the discovery that exercise provokes an increase in a number of cytokines, a possible link between skeletal muscle contractile activity and immune changes was established. For most of the last century, researchers sought a link between muscle contraction and humoral changes in the form of an "exercise factor," which could mediate some of the exercise-induced metabolic changes in other organs such as the liver and the adipose tissue. We suggest that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert either paracrine or endocrine effects should be classified as "myokines." Since the discovery of interleukin (IL)-6 release from contracting skeletal muscle, evidence has accumulated that supports an effect of IL-6 on metabolism. We suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines should be named "myokines." Interestingly, recent research demonstrates that skeletal muscles can produce and express cytokines belonging to distinctly different families. Thus skeletal muscle has the capacity to express several myokines. To date the list includes IL-6, IL-8, and IL-15, and contractile activity plays a role in regulating the expression of these cytokines in skeletal muscle. The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines.

Role of myokines in exercise and metabolism. Publishing Authors By Initials

BK Pedersen,TC ,AR Nielsen,CP Fischer,BK Pedersen,TC ,AR Nielsen,CP Fischer,

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Role of myokines in exercise and metabolism. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 103

Page Numbers: 1093-8

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 8

MONTH: 03

YEAR: 2007

Role of myokines in exercise and metabolism. Information

Number of References: 78

LANGUAGE: eng

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Grant and Affiliation Information for Role of myokines in exercise and metabolism.

AFFILIATION: Centre of Inflammation and Metabolism, 7641 Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. bkp@rh.dk

Country: United States

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MEDLINETA: J Appl Physiol

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