[Role of lysines in the stability of a snake neurotoxin]

[Role of lysines in the stability of a snake neurotoxin] Research Abstract Details 

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[Role of lysines in the stability of a snake neurotoxin] Abstract Text:

A Ménez,N Tamiya,

The effects of charge suppression at a single lysine residue on the energetics of thermal unfolding or unfolding with guanidinium chloride of erabutoxin b are studied by circular dichroism. It is shown that acylation of lysine 15, 47 or 51 has virtually no effect on the toxin stability. In contrast, abolition of the positive charge of lys-27, a residue involved in the "toxic" site of the molecule, substantially increases the toxin stability. This phenomenon is attributed to suppression of repulsive interactions occurring within the native toxin molecule between lys-27 and other positively charged groups.

[Role of lysines in the stability of a snake neurotoxin] Publishing Authors By Initials

A Ménez,N Tamiya,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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[Role of lysines in the stability of a snake neurotoxin] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Comptes rendus des séances de l'Académie des scien

VOLUME: 294

Page Numbers: 957-62

Journal Abbreviation:

ISSN: 0249-6313

DAY: 24

MONTH: May

YEAR: 1982

[Role of lysines in the stability of a snake neurotoxin] Information

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LANGUAGE: fre

NlmUniqueID: 8108553

[Role of lysines in the stability of a snake neurotoxin] Keywords Mesh Terms:

KEYWORDS: Thermodynamics

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Chemical & Substance for Abstract: [Role of lysines in the stability of a snake neurotoxin] Information

Substance Name: erabutoxin b

Registry Number: 9083-23-2

Grant and Affiliation Information for [Role of lysines in the stability of a snake neurotoxin]

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Country: FRANCE

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MEDLINETA: C R Seances Acad Sci III

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