[Role of hypothalamic orexin in drug addiction]

[Role of hypothalamic orexin in drug addiction] Research Abstract Details 

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[Role of hypothalamic orexin in drug addiction] Abstract Text:

Jin Han,Yong-Hui Li,Yun-Jing Bai,Nan Sui,

Hypothalamus is considered as an important brain region regulating natural rewards. Orexin, a neuropeptide specifically expressed in hypothalamus, arrests investigators much attention for its function in drug rewards. Orexin neurons in different brain regions exert different roles in regulating reward and motivation in the addiction research: orexin neurons in perifornical area (PFA) and dorsomedial hypothalamus (DMH) are mainly concerned with activating stress system, while orexin neurons in lateral hypothalamus participate in mediating reward-related behavior through activating brain circuitry involved in reward learning. The orexin system may therefore represent a target for preventing relapse to drug seeking during protracted abstinence. And targeting orexin receptors may provide new therapeutic strategies to treat addiction.

[Role of hypothalamic orexin in drug addiction] Publishing Authors By Initials

J Han,YH Li,YJ Bai,N Sui,

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[Role of hypothalamic orexin in drug addiction] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng li ke xue jin zhan [Progress in physiology]

VOLUME: 38

Page Numbers: 327-30

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ISSN: 0559-7765

DAY: 31

MONTH: Oct

YEAR: 2007

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LANGUAGE: chi

NlmUniqueID: 20730140

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AFFILIATION: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.

Country: China

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MEDLINETA: Sheng Li Ke Xue Jin Zhan

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