Role of glucocorticoids in the molecular regulation of muscle wasting.

Role of glucocorticoids in the molecular regulation of muscle wasting. Research Abstract Details 

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Role of glucocorticoids in the molecular regulation of muscle wasting. Abstract Text:

Michael Menconi,Moin Fareed,Patrick O'Neal,Vitaliy Poylin,Wei Wei,Per-Olof Hasselgren,

OBJECTIVE: To review glucocorticoid-regulated molecular mechanisms of muscle wasting. DESIGN: Review of recent literature describing the role of glucocorticoids in the regulation of proteolytic mechanisms, transcription factors, and nuclear cofactors in skeletal muscle during various catabolic conditions. MAIN RESULTS: Catabolic doses of glucocorticoids induce muscle atrophy both in vivo and in vitro by stimulating protein breakdown and inhibiting protein synthesis. Signaling pathways that regulate muscle protein synthesis at the translational level are inhibited by glucocorticoids. Glucocorticoids increase the expression and activity of the ubiquitin-proteasome pathway, a major proteolytic mechanism of muscle atrophy. The expression and activity of muscle wasting-related transcription factors, including C/EBPbeta and delta and Forkhead box O 1, 3, and 4, as well as the nuclear cofactor p300, are up-regulated by glucocorticoid excess. CONCLUSIONS: Muscle wasting in various catabolic conditions is, at least in part, regulated by glucocorticoids. The role of glucocorticoids in muscle wasting is complex and reflects regulation at the molecular level of multiple mechanisms influencing both synthesis and degradation of muscle proteins.

Role of glucocorticoids in the molecular regulation of muscle wasting. Publishing Authors By Initials

M Menconi,M Fareed,P O'Neal,V Poylin,W Wei,PO Hasselgren,

For similar nutritional and metabolic diseases: metabolic diseases: wasting syndrome research abstracts see: nutritional and metabolic diseases: metabolic diseases: wasting syndrome research

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Role of glucocorticoids in the molecular regulation of muscle wasting. Journal Published:

PUBLICATION TYPE: Review

Journal: Critical care medicine

VOLUME: 35

Page Numbers: S602-8

Journal Abbreviation: Crit. Care Med.

ISSN: 0090-3493

DAY: 3

MONTH: Sep

YEAR: 2007

Role of glucocorticoids in the molecular regulation of muscle wasting. Information

Number of References: 83

LANGUAGE: eng

NlmUniqueID: 355501

Role of glucocorticoids in the molecular regulation of muscle wasting. Keywords Mesh Terms:

KEYWORDS: Wasting Syndrome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of glucocorticoids in the molecular regulation of muscle wasting. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Role of glucocorticoids in the molecular regulation of muscle wasting.

AFFILIATION: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Country: United States

AGENCY: United States NINR

GRANT: R01 NR008545

ACRONYM: NR

MEDLINETA: Crit Care Med

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